NCAN_HUMAN - dbPTM
NCAN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCAN_HUMAN
UniProt AC O14594
Protein Name Neurocan core protein
Gene Name NCAN
Organism Homo sapiens (Human).
Sequence Length 1321
Subcellular Localization Secreted.
Protein Description May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid..
Protein Sequence MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNFC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
112PhosphorylationKSWQGRVSLPSYPRR
ECCCCCCCCCCCCCC		32.9523898821
122N-linked_GlycosylationSYPRRRANATLLLGP
CCCCCCCCCEEEECC		31.48UniProtKB CARBOHYD
124O-linked_GlycosylationPRRRANATLLLGPLR
CCCCCCCEEEECCCC		20.1128657654
133PhosphorylationLLGPLRASDSGLYRC
EECCCCCCCCCCEEE		26.3522210691
264PhosphorylationELGGEVFYVGPARRL
HHCCEEEEECHHHHH		15.0729083192
340N-linked_GlycosylationRTVYRFANRTGFPSP
HHHHHHHCCCCCCCH		39.06UniProtKB CARBOHYD
381PhosphorylationGDEGEILSAEGPPVR
CCCCCEECCCCCCCC		29.9028348404
401PhosphorylationLEEEEVVTPDFQEPL
CCCCCCCCCCCCCCC		23.4728348404
410PhosphorylationDFQEPLVSSGEEETL
CCCCCCCCCCCCEEE		40.0728348404
411PhosphorylationFQEPLVSSGEEETLI
CCCCCCCCCCCEEEE		42.6228348404
529PhosphorylationPPLAMAVTEMLGSGQ
CCHHHHHHHHHCCCC		13.2123879269
539PhosphorylationLGSGQSRSPWADLTN
HCCCCCCCCCHHCCC		30.0020166139
545PhosphorylationRSPWADLTNEVDMPG
CCCCHHCCCCCCCCC		29.8520166139
555PhosphorylationVDMPGAGSAGGKSSP
CCCCCCCCCCCCCCC		24.1723879269
577PhosphorylationTMVPPSISGHSRAPV
CCCCCCCCCCCCCCE		34.4926657352
580PhosphorylationPPSISGHSRAPVLEL
CCCCCCCCCCCEEEE		33.3926657352
708PhosphorylationPRADFRETGETSPAQ
CCCCHHCCCCCCHHH		35.7430576142
723PhosphorylationVNKAEHSSSSPWPSV
HCCCCCCCCCCCCCC		36.4230576142
724PhosphorylationNKAEHSSSSPWPSVN
CCCCCCCCCCCCCCC		43.3530576142
725O-linked_GlycosylationKAEHSSSSPWPSVNR
CCCCCCCCCCCCCCC		32.69OGP
871O-linked_GlycosylationALDTSIVTPLTTLEQ
ECCCCCCCCCCCCCC		15.77OGP
1026N-linked_GlycosylationHGGTCNANGTMYGCS
CCCEECCCCCEEECC		32.26UniProtKB CARBOHYD
1223N-linked_GlycosylationGPPPAVENASLIGAR
CCCCCCCCHHHCCCC		28.38UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCAN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCAN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCAN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NCAN_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCAN_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory