TCP11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCP11_HUMAN
• UniProt AC: Q8WWU5
• Protein Name: T-complex protein 11 homolog
• Gene Name: TCP11
• Organism: Homo sapiens (Human).
• Sequence Length: 503
• Subcellular Localization: Membrane ; Single-pass membrane protein . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle, acrosome . Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PR
• Protein Description: Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway..
• Protein Sequence: MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLSVTGLTETVNEVSKLSNKIGMNCDYYMEEKVLPPSSLEGKVKETVHNAFWDHLKEQLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAEHGALKVLYLSKYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQYERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLCQGFLNLLLWDLENEEFPETLLMDRTRLQELKSQLHQLTVMASVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEEAILTVSEQVSQEIHQSLKNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 4)	Phosphorylation	-	55.92	30622161
7	Phosphorylation	-MPDVKESVPPKYPG -CCCHHHCCCCCCCC	33.92	20393185
11 (in isoform 4)	Phosphorylation	-	58.99	30622161
13 (in isoform 4)	Phosphorylation	-	46.36	30622161
44	Phosphorylation	EDPPPFLSVTGLTET CCCCCCEEECCCHHH	20.29	30622161
46	Phosphorylation	PPPFLSVTGLTETVN CCCCEEECCCHHHHH	24.09	25693802
59	Phosphorylation	VNEVSKLSNKIGMNC HHHHHHHHHHHCCCC	39.55	-
68	Phosphorylation	KIGMNCDYYMEEKVL HHCCCCCCHHCCCCC	13.60	30622161
69	Phosphorylation	IGMNCDYYMEEKVLP HCCCCCCHHCCCCCC	5.70	30622161
78	Phosphorylation	EEKVLPPSSLEGKVK CCCCCCHHHCCCHHH	45.69	30622161
79	Phosphorylation	EKVLPPSSLEGKVKE CCCCCHHHCCCHHHH	35.89	30622161
101	Phosphorylation	DHLKEQLSATPPDFS HHHHHHHCCCCCCCH	29.77	30622161
103	Phosphorylation	LKEQLSATPPDFSCA HHHHHCCCCCCCHHH	31.79	30622161
239	Phosphorylation	ELLNKQPSLLNHTTK HHHHCCHHHHHHHHH	42.89	30622161
244	Phosphorylation	QPSLLNHTTKWLTQA CHHHHHHHHHHHHHH	29.06	25693802
245	Phosphorylation	PSLLNHTTKWLTQAA HHHHHHHHHHHHHHH	16.81	25693802
401	Phosphorylation	NMGLVALSSDNTASL HCCEEEECCCCHHHH	26.38	25693802
402	Phosphorylation	MGLVALSSDNTASLM CCEEEECCCCHHHHH	35.41	25693802
405	Phosphorylation	VALSSDNTASLMGQL EEECCCCHHHHHHHH	23.71	30622161
407	Phosphorylation	LSSDNTASLMGQLQN ECCCCHHHHHHHHHH	19.49	30622161
445	Phosphorylation	LVLGVQRSLLDLPGG HHHHHHHHHHCCCCC	19.05	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCP11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCP11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCP11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.