dbPTM

TCP10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TCP10_HUMAN
UniProt AC	Q12799
Protein Name	T-complex protein 10A homolog
Gene Name	TCP10
Organism	Homo sapiens (Human).
Sequence Length	353
Subcellular Localization
Protein Description
Protein Sequence	MLEGQLEAGEPKEGTHPEDPCPGAGAAMEKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRELREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQSATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSPAPTGRPTPGAERRGVSEDGKIMHPSSRSPQNSGGRKSPVQASQATTLQEQTAAARGADRSSSVLGSSEGGFLSRVQADEFASSAPDSAERQNLPVNPPSSLEIAQAMDTKMKKEEVQEEKRHPKGKADDCRRSGFPSEFPGALHAAPSRQDMGP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	QLEAGEPKEGTHPED CCCCCCCCCCCCCCC	65.56	7468559
30	Acetylation	GAGAAMEKTPAAAEV CCCHHCCCCCCCCCC	46.88	7468567
202	Phosphorylation	QDRSPAPTGRPTPGA CCCCCCCCCCCCCCC	48.18	-
281	Phosphorylation	VQADEFASSAPDSAE HCHHHHHHCCCCHHH	32.14	28634298
282	Phosphorylation	QADEFASSAPDSAER CHHHHHHCCCCHHHH	40.15	28634298
286	Phosphorylation	FASSAPDSAERQNLP HHHCCCCHHHHCCCC	30.85	28634298
332	Phosphorylation	KADDCRRSGFPSEFP CHHHHHHCCCCCCCC	25.98	24719451
336	Phosphorylation	CRRSGFPSEFPGALH HHHCCCCCCCCCCCC	50.00	23607784
347	Phosphorylation	GALHAAPSRQDMGP- CCCCCCCCCCCCCC-	37.54	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TCP10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TCP10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TCP10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TCP10_HUMAN

Related Literatures of Post-Translational Modification