TBCC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCC_HUMAN
• UniProt AC: Q15814
• Protein Name: Tubulin-specific chaperone C
• Gene Name: TBCC
• Organism: Homo sapiens (Human).
• Sequence Length: 346
• Subcellular Localization: Cytoplasm . Detected predominantly in the photoreceptor connecting cilium.
• Protein Description: Tubulin-folding protein; involved in the final step of the tubulin folding pathway..
• Protein Sequence: MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESVSCSA -------CCCCCCCE	8.59	22223895
80	Phosphorylation	ELLERAESVERLEEA HHHHHHHHHHHHHHH	28.44	22617229
89	Phosphorylation	ERLEEAASRLQGLQK HHHHHHHHHHHHHHH	40.34	23090842
148	Phosphorylation	TRGKDAASSTKVDAA ECCCCCCCCCCCCCC	40.02	24719451
149	Phosphorylation	RGKDAASSTKVDAAP CCCCCCCCCCCCCCC	27.76	28857561
150	Phosphorylation	GKDAASSTKVDAAPG CCCCCCCCCCCCCCC	32.37	28857561
151	Ubiquitination	KDAASSTKVDAAPGI CCCCCCCCCCCCCCC	39.81	-
164	Phosphorylation	GIPPAVESIQDSPLP CCCCCHHHHCCCCCC	20.96	21815630
168	Phosphorylation	AVESIQDSPLPKKAE CHHHHCCCCCCCCCC	16.38	25159151
172	Ubiquitination	IQDSPLPKKAEGDLG HCCCCCCCCCCCCCC	72.76	29967540
173	Ubiquitination	QDSPLPKKAEGDLGP CCCCCCCCCCCCCCC	50.13	29967540
196	Ubiquitination	LESQVLEKRASELHQ HHHHHHHHHHHHHHH	49.45	29967540
199	Phosphorylation	QVLEKRASELHQRDV HHHHHHHHHHHHHHH	44.73	28102081
219	Phosphorylation	SNCTVRLYGNPNTLR CCCEEEECCCCCCCC	12.32	-
276	Phosphorylation	TRIFLQVTSRAIVED CHHEEEEECHHHHHC	10.26	-
277	Phosphorylation	RIFLQVTSRAIVEDC HHEEEEECHHHHHCC	22.36	-
312	Ubiquitination	SSGLDRSKNNWNDVD HCCCCCCCCCCCCHH	56.01	29967540
330	Phosphorylation	WLARDMASPNWSILP HHHHHCCCCCCCCCC	16.48	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.
PubMed: 18669648