dbPTM

TAL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAL1_MOUSE
UniProt AC	P22091
Protein Name	T-cell acute lymphocytic leukemia protein 1 homolog
Gene Name	Tal1
Organism	Mus musculus (Mouse).
Sequence Length	329
Subcellular Localization	Nucleus .
Protein Description	Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation..
Protein Sequence	MTERPPSEAARSDPQLEGQDAAEARMAPPHLVLLNGVAKETSRAAPAEPPVIELGARSGAGGGPASGGGAARDLKGRDAVAAEARLRVPTTELCRPPGPAPAPAPASAPAELPGDGRMVQLSPPALAAPAGPGRALLYSLSQPLASLGSGFFGEPDAFPMFTNNNRVKRRPSPYEMEISDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKPGKDPVVGAGGGGAGGGIPPEDLLQDVLSPNSSCGSSLDGAASPDSYTEEPTPKHTSRSLHPALLPAADGAGPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MTERPPSEAARSDP -CCCCCHHHHHHCCC	42.42	30482847
12	Phosphorylation	PPSEAARSDPQLEGQ CHHHHHHCCCCCCCC	49.25	-
58	Phosphorylation	VIELGARSGAGGGPA EEEECCCCCCCCCCC	32.25	21454597
66	Phosphorylation	GAGGGPASGGGAARD CCCCCCCCCCHHHCC	40.90	21454597
122	Phosphorylation	DGRMVQLSPPALAAP CCCEEEECCCCCCCC	16.25	22942356
172	Phosphorylation	NRVKRRPSPYEMEIS CCCCCCCCCCEEEEC	38.00	22817900
216	Phosphorylation	ELRKLIPTHPPDKKL HHHHHCCCCCCCCCC	39.77	-
221	Acetylation	IPTHPPDKKLSKNEI CCCCCCCCCCCHHHH	62.48	60395
222	Acetylation	PTHPPDKKLSKNEIL CCCCCCCCCCHHHHH	66.43	60399

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
122	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
122	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
122	S	Phosphorylation	Kinase	MAPK	-	Uniprot
172	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
122	S	Phosphorylation	11904294
Phosphorylation of Ser-122 by MAPK is strongly stimulated by hypoxia.
122	S	Phosphorylation	11904294
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system.
122	S	ubiquitylation	11904294
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_MOUSE	Sin3a	physical	10688671
HDAC1_MOUSE	Hdac1	physical	10688671
TRI27_MOUSE	Trim27	physical	16007160
LMO3_MOUSE	Lmo3	physical	20211142
GATA1_MOUSE	Gata1	physical	15920471
LDB1_MOUSE	Ldb1	physical	15920471
KDM1A_MOUSE	Kdm1a	physical	19497860
HDAC1_MOUSE	Hdac1	physical	19497860
RCOR2_MOUSE	Rcor2	physical	19497860
KAT2B_MOUSE	Kat2b	physical	11118214
SIN3A_MOUSE	Sin3a	physical	11118214

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAL1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation by mitogen-activated protein kinase mediates thehypoxia-induced turnover of the TAL1/SCL transcription factor inendothelial cells."; Tang T., Arbiser J.L., Brandt S.J.; J. Biol. Chem. 277:18365-18372(2002). Cited for: PHOSPHORYLATION AT SER-122, MUTAGENESIS OF SER-122, ANDUBIQUITINATION.	11904294 [Abstract]