TAGL_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAGL_RAT
• UniProt AC: P31232
• Protein Name: Transgelin
• Gene Name: Tagln
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 201
• Subcellular Localization: Cytoplasm .
• Protein Description: Actin cross-linking/gelling protein..
• Protein Sequence: MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIVMQCGPDVGRPDRGRLGFQVWLKNGVILSKLVNSLYPEGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVTKTDMFQTVDLFEGKDMAAVQRTVMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTDSQLQEGKHVIGLQMGSNRGASQAGMTGYGRPRQIIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANKGPSYG ------CCCCCCCCC	26.83	-
4	Acetylation	----MANKGPSYGMS ----CCCCCCCCCCC	63.76	22902405
17	Acetylation	MSREVQSKIEKKYDE CCHHHHHHHHHHCCH	37.48	22902405
20	Acetylation	EVQSKIEKKYDEELE HHHHHHHHHCCHHHH	61.17	22902405
21	Succinylation	VQSKIEKKYDEELEE HHHHHHHHCCHHHHH	45.18	26843850
21	Ubiquitination	VQSKIEKKYDEELEE HHHHHHHHCCHHHHH	45.18	-
21	Acetylation	VQSKIEKKYDEELEE HHHHHHHHCCHHHHH	45.18	22902405
75	Acetylation	SLYPEGSKPVKVPEN HHCCCCCCCCCCCCC	65.76	22902405
78	Acetylation	PEGSKPVKVPENPPS CCCCCCCCCCCCCCC	61.68	22902405
89	Acetylation	NPPSMVFKQMEQVAQ CCCCHHHHHHHHHHH	37.01	22902405
99	Acetylation	EQVAQFLKAAEDYGV HHHHHHHHHHHHHCC	47.00	22902405
108	Acetylation	AEDYGVTKTDMFQTV HHHHCCCCCCCCCEE	39.87	22902405
121	Acetylation	TVDLFEGKDMAAVQR EECCCCCCCHHHHHH	36.81	22902405
139	Phosphorylation	ALGSLAVTKNDGHYR HHCCEEEECCCCCCC	20.65	-
154	Acetylation	GDPNWFMKKAQEHKR CCCCHHHHHHHHHHH	35.17	22902405
164	Phosphorylation	QEHKREFTDSQLQEG HHHHHCCCHHHHHCC	29.95	23984901
166	Phosphorylation	HKREFTDSQLQEGKH HHHCCCHHHHHCCCE	29.72	23984901
172	Acetylation	DSQLQEGKHVIGLQM HHHHHCCCEEEEEEC	33.67	22902405
181	Phosphorylation	VIGLQMGSNRGASQA EEEEECCCCCCCHHC	20.29	22673903
183	Methylation	GLQMGSNRGASQAGM EEECCCCCCCHHCCC	43.69	18871605
186	Phosphorylation	MGSNRGASQAGMTGY CCCCCCCHHCCCCCC	24.32	22673903
193	Phosphorylation	SQAGMTGYGRPRQII HHCCCCCCCCCCCCC	10.78	-
195	Methylation	AGMTGYGRPRQIIS- CCCCCCCCCCCCCC-	18.10	18959179

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
139	T	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
181	S	Phosphorylation	Kinase	PKCD	Q05655	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAGL_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAGL_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G6PD_RAT	G6pd	physical	26291555
G6PD1_MOUSE	G6pdx	physical	26291555
TRAF6_RAT	Traf6	physical	26291555

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.