TACO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TACO1_HUMAN
• UniProt AC: Q9BSH4
• Protein Name: Translational activator of cytochrome c oxidase 1
• Gene Name: TACO1
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Mitochondrion .
• Protein Description: Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1..
• Protein Sequence: MSAWAAASLSRAAARCLLARGPGVRAAPPRDPRPSHPEPRGCGAAPGRTLHFTAAVPAGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKSTIETALKMEKSKDTYLLYEGRGPGGSSLLIEALSNSSHKCQADIRHILNKNGGVMAVGARHSFDKKGVIVVEVEDREKKAVNLERALEMAIEAGAEDVKETEDEEERNVFKFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDNIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	O-linked_Glycosylation	------MSAWAAASL ------CCHHHHHHH	32.30	30379171
8	Phosphorylation	MSAWAAASLSRAAAR CCHHHHHHHHHHHHH	23.35	27174698
10	Phosphorylation	AWAAASLSRAAARCL HHHHHHHHHHHHHHH	19.85	27174698
82	Phosphorylation	VERSRIFSKLCLNIR HHHHHHHHHHHHHHH	23.50	24719451
112	Glutathionylation	LANILEVCRSKHMPK HHHHHHHHHCCCCCH	2.72	22555962
119	Acetylation	CRSKHMPKSTIETAL HHCCCCCHHHHHHHH	53.29	20167786
131	Phosphorylation	TALKMEKSKDTYLLY HHHHHHHCCCEEEEE	23.58	25849741
132	2-Hydroxyisobutyrylation	ALKMEKSKDTYLLYE HHHHHHCCCEEEEEE	66.22	-
134	Phosphorylation	KMEKSKDTYLLYEGR HHHHCCCEEEEEECC	21.58	20068231
135	Phosphorylation	MEKSKDTYLLYEGRG HHHCCCEEEEEECCC	12.58	27642862
138	Phosphorylation	SKDTYLLYEGRGPGG CCCEEEEEECCCCCH	17.47	27642862
154	Phosphorylation	SLLIEALSNSSHKCQ HHHHHHHHCCCCCHH	41.53	28555341
170	Malonylation	DIRHILNKNGGVMAV HHHHHHHHCCCEEEE	54.23	26320211
170	Ubiquitination	DIRHILNKNGGVMAV HHHHHHHHCCCEEEE	54.23	21890473
170	Acetylation	DIRHILNKNGGVMAV HHHHHHHHCCCEEEE	54.23	25953088
199	2-Hydroxyisobutyrylation	EVEDREKKAVNLERA EECCHHHHHCCHHHH	53.46	-
221	Phosphorylation	GAEDVKETEDEEERN CCCCHHCCCCHHHHC	42.91	-
234	Glutathionylation	RNVFKFICDASSLHQ HCHHHHHHCHHHHHH	3.93	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TACO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TACO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TACO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
G3P_HUMAN	GAPDH	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 256000: Leigh syndrome (LS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.