TAB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAB3_MOUSE
• UniProt AC: Q571K4
• Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
• Gene Name: Tab3
• Organism: Mus musculus (Mouse).
• Sequence Length: 716
• Protein Description: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL-1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor (By similarity)..
• Protein Sequence: MAQNSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPEDNRMNRNRLLHINLGIHSPSSYHPGDGAHLNGGRTLVHSSSDGHIDPQHTAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIFIRQTSQSSSGRQTPQNAPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSVYHSPPPSQCPSPFSSPQHQVQPPQLGHPSSHVFMPPSPSTTPPHLYQQGPPSYQKPGSHSVAYLPYTASSLPKGSMKKIEITVEPSQRPGTAITRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCAPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGNHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKAEVNSMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSTNRQLQINVDCTLKEVDLLQSRGNFDPKAINNFYDHIEPGPVVPPKPSKKDSSDSCAIERKARRISVTSKAPVDIHDAQAAAADEHLSICKQSARTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQNSPQLD ------CCCCCCCHH	19.77	-
5	Phosphorylation	---MAQNSPQLDIQV ---CCCCCCCHHHHH	11.27	30352176
58	Phosphorylation	SKYLYMEYHSPEDNR HHHHHEEECCCCCCC	7.35	20415495
60	Phosphorylation	YLYMEYHSPEDNRMN HHHEEECCCCCCCCC	29.14	21183079
80	Phosphorylation	HINLGIHSPSSYHPG EEECCCCCCCCCCCC	25.26	21183079
84	Phosphorylation	GIHSPSSYHPGDGAH CCCCCCCCCCCCCCC	19.17	21183079
97	Phosphorylation	AHLNGGRTLVHSSSD CCCCCCCEEEECCCC	36.09	30635358
101	Phosphorylation	GGRTLVHSSSDGHID CCCEEEECCCCCCCC	24.86	21082442
102	Phosphorylation	GRTLVHSSSDGHIDP CCEEEECCCCCCCCC	19.99	29899451
103	Phosphorylation	RTLVHSSSDGHIDPQ CEEEECCCCCCCCCC	51.10	30352176
112	Phosphorylation	GHIDPQHTAGKQLIC CCCCCCCCCCCEEEE	31.68	29472430
126	Phosphorylation	CLVQEPHSAPAVVAA EEEECCCCCCEEEEE	46.81	26745281
134	Phosphorylation	APAVVAATPNYNPFF CCEEEEECCCCCCCC	11.43	23984901
198	Phosphorylation	STNPITVTVSQNLPS CCCCEEEEEEECCCC	13.04	-
377	Phosphorylation	IEITVEPSQRPGTAI EEEEECCCCCCCCCE	25.89	21183079
382	Phosphorylation	EPSQRPGTAITRSPS CCCCCCCCCEECCCC	19.98	25338131
385	O-linked_Glycosylation	QRPGTAITRSPSPIS CCCCCCEECCCCCCC	23.72	22517741
385	Phosphorylation	QRPGTAITRSPSPIS CCCCCCEECCCCCCC	23.72	-
387	Phosphorylation	PGTAITRSPSPISNQ CCCCEECCCCCCCCC	22.53	23527152
389	Phosphorylation	TAITRSPSPISNQPS CCEECCCCCCCCCCC	35.79	23527152
392	Phosphorylation	TRSPSPISNQPSPRN ECCCCCCCCCCCCCC	32.56	23737553
396	Phosphorylation	SPISNQPSPRNQHSL CCCCCCCCCCCCCCC	27.08	23737553
402	Phosphorylation	PSPRNQHSLYTATTP CCCCCCCCCEEECCC	17.20	18846507
404	Phosphorylation	PRNQHSLYTATTPPS CCCCCCCEEECCCCC	9.42	18846507
405	Phosphorylation	RNQHSLYTATTPPSS CCCCCCEEECCCCCC	23.87	26643407
407	Phosphorylation	QHSLYTATTPPSSSP CCCCEEECCCCCCCC	31.84	26643407
408	Phosphorylation	HSLYTATTPPSSSPS CCCEEECCCCCCCCC	30.64	25521595
411	O-linked_Glycosylation	YTATTPPSSSPSRGI EEECCCCCCCCCCCC	44.65	22517741
411	Phosphorylation	YTATTPPSSSPSRGI EEECCCCCCCCCCCC	44.65	26643407
412	O-linked_Glycosylation	TATTPPSSSPSRGIS EECCCCCCCCCCCCC	52.63	22517741
412	Phosphorylation	TATTPPSSSPSRGIS EECCCCCCCCCCCCC	52.63	18846507
413	Phosphorylation	ATTPPSSSPSRGISS ECCCCCCCCCCCCCC	31.09	26643407
413	O-linked_Glycosylation	ATTPPSSSPSRGISS ECCCCCCCCCCCCCC	31.09	22517741
415	Phosphorylation	TPPSSSPSRGISSQP CCCCCCCCCCCCCCC	45.12	18846507
462	Phosphorylation	PTTVFKITVGRATTE CCEEEEEEECCCHHH	19.94	23984901
467	Phosphorylation	KITVGRATTENLLNL EEEECCCHHHHHHHH	33.03	23984901
468	Phosphorylation	ITVGRATTENLLNLV EEECCCHHHHHHHHC	23.14	23984901
496	Phosphorylation	PISVIPGSGGEKGNH CCEEECCCCCCCCCC	37.97	25338131
508	Phosphorylation	GNHKYQRSSSSGSDD CCCCCCCCCCCCCCH	21.03	28833060
509	Phosphorylation	NHKYQRSSSSGSDDY CCCCCCCCCCCCCHH	30.61	28833060
510	Phosphorylation	HKYQRSSSSGSDDYA CCCCCCCCCCCCHHH	39.71	25521595
511	Phosphorylation	KYQRSSSSGSDDYAY CCCCCCCCCCCHHHH	44.24	28833060
513	Phosphorylation	QRSSSSGSDDYAYTQ CCCCCCCCCHHHHHH	29.29	28833060
516	Phosphorylation	SSSGSDDYAYTQALL CCCCCCHHHHHHHHH	13.39	28833060
518	Phosphorylation	SGSDDYAYTQALLLH CCCCHHHHHHHHHHH	7.99	28833060
519	Phosphorylation	GSDDYAYTQALLLHQ CCCHHHHHHHHHHHH	10.13	28833060
649	Phosphorylation	ERKARRISVTSKAPV HHHHHCEECCCCCCC	19.96	25266776
651	Phosphorylation	KARRISVTSKAPVDI HHHCEECCCCCCCCH	20.09	25367039
652	Phosphorylation	ARRISVTSKAPVDIH HHCEECCCCCCCCHH	25.35	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
510	S	Phosphorylation	Kinase	MAPKAPK2	P49138	Uniprot
510	S	Phosphorylation	Kinase	MAPKAPK3	Q3UMW7	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
510	S	Phosphorylation	Phosphorylated at Ser-510 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAB3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_MOUSE	Ubc	physical	19136968
BECN1_MOUSE	Becn1	physical	21976705

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.