| UniProt ID | T53I2_HUMAN | |
|---|---|---|
| UniProt AC | Q8IXH6 | |
| Protein Name | Tumor protein p53-inducible nuclear protein 2 | |
| Gene Name | TP53INP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 220 | |
| Subcellular Localization | Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. | |
| Protein Description | Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.. | |
| Protein Sequence | MFQRLSSLFFSTPSPPEDPDCPRAFVSEEDEVDGWLIIDLPDSYAAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSSPLEDLLIEHPSMSVYVTGSTIVLEPGSPSPLPDAALPDGDLSEGELTPARREPRAARHAAPLPARAALLEKAGQVRRLQRARQRAERHALSAKAVQRQNRARESRPRRSKNQSSFIYQPCQRQFNY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MFQRLSSLFFSTP --CCHHHHHHHCCCC | 27.47 | 27174698 | |
| 7 | Phosphorylation | -MFQRLSSLFFSTPS -CCHHHHHHHCCCCC | 33.51 | 27174698 | |
| 11 | Phosphorylation | RLSSLFFSTPSPPED HHHHHHCCCCCCCCC | 31.88 | 22199227 | |
| 12 | Phosphorylation | LSSLFFSTPSPPEDP HHHHHCCCCCCCCCC | 23.72 | 22199227 | |
| 14 | Phosphorylation | SLFFSTPSPPEDPDC HHHCCCCCCCCCCCC | 53.85 | 22617229 | |
| 49 | Phosphorylation | DSYAAPPSPGAAPAP CCCCCCCCCCCCCCC | 34.60 | 26074081 | |
| 65 | Phosphorylation | GRPPPAPSLMDESWF CCCCCCCCCCCCCCE | 38.13 | 26074081 | |
| 70 | Phosphorylation | APSLMDESWFVTPPA CCCCCCCCCEECCCC | 22.88 | 26074081 | |
| 136 | Phosphorylation | ALPDGDLSEGELTPA CCCCCCCCCCCCCCC | 48.58 | 24275569 | |
| 165 | Ubiquitination | ARAALLEKAGQVRRL HHHHHHHHHHHHHHH | 58.76 | 32142685 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of T53I2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of T53I2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of T53I2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MLP3A_HUMAN | MAP1LC3A | physical | 20010805 | |
| GBRL2_HUMAN | GABARAPL2 | physical | 20010805 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12 AND SER-14, AND MASSSPECTROMETRY. | |
