T106C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T106C_HUMAN
• UniProt AC: Q9BVX2
• Protein Name: Transmembrane protein 106C
• Gene Name: TMEM106C
• Organism: Homo sapiens (Human).
• Sequence Length: 250
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Membrane ; Lipid-anchor .
• Protein Sequence: MGSQHSAAARPSSCRRKQEDDRDGLLAEREQEEAIAQFPYVEFTGRDSITCLTCQGTGYIPTEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKVVKVTFNKQDSLVILTIMATLKIRNSNFYTVAVTSLSSQIQYMNTVVSTYVTTNVSLIPPRSEQLVNFTGKAEMGGPFSYVYFFCTVPEILVHNIVIFMRTSVKISYIGLMTQSSLETHHYVDCGGNSTAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSQHSAAA ------CCCCCCCCC	35.69	25807930
17	Ubiquitination	RPSSCRRKQEDDRDG CCHHHCCCCCCCCCC	38.39	33845483
40	Phosphorylation	EAIAQFPYVEFTGRD HHHHCCCCEEEECCC	17.56	25147952
44	Phosphorylation	QFPYVEFTGRDSITC CCCCEEEECCCCEEE	20.15	26074081
48	Phosphorylation	VEFTGRDSITCLTCQ EEEECCCCEEEEEEC	20.59	26074081
50	Phosphorylation	FTGRDSITCLTCQGT EECCCCEEEEEECCC	12.86	26074081
53	Phosphorylation	RDSITCLTCQGTGYI CCCEEEEEECCCCEE	12.62	26074081
57	Phosphorylation	TCLTCQGTGYIPTEQ EEEEECCCCEECHHH	10.84	26074081
59	Phosphorylation	LTCQGTGYIPTEQVN EEECCCCEECHHHHH	11.99	26074081
62	Phosphorylation	QGTGYIPTEQVNELV CCCCEECHHHHHHHH	29.50	26074081
139	Phosphorylation	VILTIMATLKIRNSN EEEEEEEEEEECCCC	15.94	22210691
173	N-linked_Glycosylation	VSTYVTTNVSLIPPR EEEEEEECCCCCCCC	16.41	UniProtKB CARBOHYD
186	N-linked_Glycosylation	PRSEQLVNFTGKAEM CCCHHHEECCCEECC	37.04	UniProtKB CARBOHYD
201	Phosphorylation	GGPFSYVYFFCTVPE CCCEEEEEEEECCHH	5.23	32142685
220	Phosphorylation	NIVIFMRTSVKISYI HEEEEEECCCEEEEE	26.53	32142685
221	Phosphorylation	IVIFMRTSVKISYIG EEEEEECCCEEEEEE	15.85	29083192
225	Phosphorylation	MRTSVKISYIGLMTQ EECCCEEEEEEEECC	12.65	29083192
226	Phosphorylation	RTSVKISYIGLMTQS ECCCEEEEEEEECCC	11.50	29083192
231	Phosphorylation	ISYIGLMTQSSLETH EEEEEEECCCCCEEE	30.27	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T106C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T106C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T106C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.