SYWM_HUMAN - dbPTM
SYWM_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYWM_HUMAN
UniProt AC Q9UGM6
Protein Name Tryptophan--tRNA ligase, mitochondrial
Gene Name WARS2
Organism Homo sapiens (Human).
Sequence Length 360
Subcellular Localization Mitochondrion matrix .
Protein Description Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis..
Protein Sequence MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MALHSMRKARER
---CCCHHHHHHHHH		22.57-
23PhosphorylationIRALHKGSAAAPALQ
HHHHHHCCCCCHHHC		21.38-
91PhosphorylationDPAVLRQSILDMTAV
CHHHHHHHHHHHHHH		20.7720068231
96PhosphorylationRQSILDMTAVLLACG
HHHHHHHHHHHHHCC		17.1820068231
116UbiquitinationSILFQQSQVSEHTQL
CHHHCCCCCCHHHHH		38.1224816145
137UbiquitinationMVRLPRLQHLHQWKA
HHHCHHHHHHHHHCC		38.0724816145
143UbiquitinationLQHLHQWKAKTTKQK
HHHHHHHCCCCCCCC		33.1724816145
150AcetylationKAKTTKQKHDGTVGL
CCCCCCCCCCCCEEH		45.2626051181
164UbiquitinationLLTYPVLQAADILLY
HHHHHHHHHHHHHHH		34.4424816145
172UbiquitinationAADILLYKSTHVPVG
HHHHHHHCCCCCCCC		49.1724816145
193UbiquitinationMELVQDLAQGFNKKY
HHHHHHHHHHHHHHH		18.7524816145
200PhosphorylationAQGFNKKYGEFFPVP
HHHHHHHHCCCCCCC		24.4019835603
206UbiquitinationKYGEFFPVPESILTS
HHCCCCCCCHHHHHH		7.4924816145
209PhosphorylationEFFPVPESILTSMKK
CCCCCCHHHHHHHHH		19.4819835603
210UbiquitinationFFPVPESILTSMKKV
CCCCCHHHHHHHHHH		4.6624816145
211UbiquitinationFPVPESILTSMKKVK
CCCCHHHHHHHHHHH		3.9524816145
212PhosphorylationPVPESILTSMKKVKS
CCCHHHHHHHHHHHH		25.7119835603
213PhosphorylationVPESILTSMKKVKSL
CCHHHHHHHHHHHHC		25.7619835603
224PhosphorylationVKSLRDPSAKMSKSD
HHHCCCCCHHCCCCC		44.82-
227UbiquitinationLRDPSAKMSKSDPDK
CCCCCHHCCCCCHHH		6.4524816145
229UbiquitinationDPSAKMSKSDPDKLA
CCCHHCCCCCHHHCC		56.2124816145
230O-linked_GlycosylationPSAKMSKSDPDKLAT
CCHHCCCCCHHHCCE		47.2530379171
231UbiquitinationSAKMSKSDPDKLATV
CHHCCCCCHHHCCEE		60.1924816145
232UbiquitinationAKMSKSDPDKLATVR
HHCCCCCHHHCCEEE		47.9624816145
234AcetylationMSKSDPDKLATVRIT
CCCCCHHHCCEEEEC		45.4726051181
241PhosphorylationKLATVRITDSPEEIV
HCCEEEECCCHHHHH		21.6222617229
250UbiquitinationSPEEIVQKFRKAVTD
CHHHHHHHHHHHHCC		35.9224816145
253MalonylationEIVQKFRKAVTDFTS
HHHHHHHHHHCCCCC		50.7926320211
299PhosphorylationRRSAGMNTARYKLAV
HHHCCCCHHHHHHHH		12.01-
302PhosphorylationAGMNTARYKLAVADA
CCCCHHHHHHHHHHH		14.11-
341UbiquitinationVLQIGSAKAKELAYT
HHHHCCHHHHHHHHH		62.7829967540
354AcetylationYTVCQEVKKLVGFL-
HHHHHHHHHHHCCC-		39.3726051181
354SuccinylationYTVCQEVKKLVGFL-
HHHHHHHHHHHCCC-		39.3727452117
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYWM_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYWM_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYWM_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00150L-Tryptophan
Regulatory Network of SYWM_HUMAN

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Related Literatures of Post-Translational Modification

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