SYCP1_HUMAN - dbPTM
SYCP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYCP1_HUMAN
UniProt AC Q15431
Protein Name Synaptonemal complex protein 1
Gene Name SYCP1
Organism Homo sapiens (Human).
Sequence Length 976
Subcellular Localization Nucleus . Chromosome . Chromosome, centromere . In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into t
Protein Description Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility..
Protein Sequence MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIAKMDRKKKLKEAEKLFV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationVPPRSSSSQVSAVKP
CCCCCCCCCCCCCCC		36.2330576142
27PhosphorylationVSAVKPQTLGGDSTF
CCCCCCCCCCCCCHH		35.5830576142
111AcetylationRVYSKLYKEAEKIKK
HHHHHHHHHHHHHHC		61.9770757
1112-HydroxyisobutyrylationRVYSKLYKEAEKIKK
HHHHHHHHHHHHHHC		61.97-
157AcetylationELQFGNEKVSLKLEE
HHCCCCCCEEHHHHH		40.9211791349
161AcetylationGNEKVSLKLEEGIQE
CCCCEEHHHHHHHHH		46.4711791361
170AcetylationEEGIQENKDLIKENN
HHHHHHCHHHHHHCH		53.8311791373
211PhosphorylationREETRQVYMDLNNNI
CHHHHHHHHHCCHHH		4.0629083192
257PhosphorylationIQHLEQEYKKEINDK
HHHHHHHHHHHCCHH		27.3622817900
269PhosphorylationNDKEKQVSLLLIQIT
CHHHHHHHEEEEEEH		15.7124043423
276PhosphorylationSLLLIQITEKENKMK
HEEEEEEHHHHHHHH		25.3224043423
295UbiquitinationLLEESRDKVNQLEEK
HHHHHHHHHHHHHHH		41.8117370265
307PhosphorylationEEKTKLQSENLKQSI
HHHHHHCHHHHHHHH		38.6023403867
313PhosphorylationQSENLKQSIEKQHHL
CHHHHHHHHHHHHHH		31.0023403867
409PhosphorylationEDQLKILTMELQKKS
HHHHHHHHHHHHHHH		16.4530243723
426O-linked_GlycosylationLEEMTKLTNNKEVEL
HHHHHHHCCCCCCCH		38.00OGP
445PhosphorylationKVLGEKETLLYENKQ
HHHCCHHHHHHHCHH		32.8830622161
448PhosphorylationGEKETLLYENKQFEK
CCHHHHHHHCHHHHH		22.1430622161
524PhosphorylationTSHCNKLSLENKELT
HHHHHHHHHCCHHHC		34.9324702127
639PhosphorylationESKQLNVYEIKVNKL
HHHCCEEEEEEECHH		15.7428674151
664PhosphorylationFGEITDTYQKEIEDK
HHHHHHHHHHHHHHC		22.01-
684AcetylationNLLEEVEKAKVIADE
HHHHHHHHHHHHHHH		59.7023236377
721PhosphorylationMEKHKHQYDKIIEER
HHHHHHHHHHHHHHH		20.94-
735PhosphorylationRDSELGLYKSKEQEQ
HHHHHCCCCCHHHHH		16.0629396449
743PhosphorylationKSKEQEQSSLRASLE
CCHHHHHHHHHHHHH		30.5021406692
744PhosphorylationSKEQEQSSLRASLEI
CHHHHHHHHHHHHHH		22.9021406692
762PhosphorylationNLKAELLSVKKQLEI
HHHHHHHHHHHHHHH		44.5124719451
785PhosphorylationKREAKENTATLKEKK
HHHHHHHCCCHHHHC		23.31-
789UbiquitinationKENTATLKEKKDKKT
HHHCCCHHHHCCCCC		64.23-
791UbiquitinationNTATLKEKKDKKTQT
HCCCHHHHCCCCCCE		65.76-
796PhosphorylationKEKKDKKTQTFLLET
HHHCCCCCCEEEECC		38.2824043423
798PhosphorylationKKDKKTQTFLLETPE
HCCCCCCEEEECCCC		22.8324043423
803PhosphorylationTQTFLLETPEIYWKL
CCEEEECCCCCEEEE		26.6224043423
807PhosphorylationLLETPEIYWKLDSKA
EECCCCCEEEECCCC		8.5324043423
819PhosphorylationSKAVPSQTVSRNFTS
CCCCCCCCCCCCCCC		25.45-
838PhosphorylationISKDKRDYLWTSAKN
CCCCCCHHCHHCCCC		14.2621394647
846PhosphorylationLWTSAKNTLSTPLPK
CHHCCCCCCCCCCCC		22.7524719451
855PhosphorylationSTPLPKAYTVKTPTK
CCCCCCCEECCCCCC		20.4224719451
861PhosphorylationAYTVKTPTKPKLQQR
CEECCCCCCCCCHHH		66.2724719451
892PhosphorylationAFEFDINSDSSETTD
EEEEECCCCCCHHHH		38.92-
894PhosphorylationEFDINSDSSETTDLL
EEECCCCCCHHHHHH		29.8722210691
895PhosphorylationFDINSDSSETTDLLS
EECCCCCCHHHHHHH		43.9122210691
909PhosphorylationSMVSEEETLKTLYRN
HHCCHHHHHHHHHHC		36.5122210691
927AcetylationPASHLCVKTPKKAPS
CHHHCEECCCCCCCC		59.107826047
934PhosphorylationKTPKKAPSSLTTPGS
CCCCCCCCCCCCCCC		42.72-
937PhosphorylationKKAPSSLTTPGSTLK
CCCCCCCCCCCCEEE		32.65-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYCP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYCP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYCP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CREB1_HUMANCREB1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYCP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-257, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-295, AND MASSSPECTROMETRY.

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