dbPTM

SWI5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SWI5_HUMAN
UniProt AC	Q1ZZU3
Protein Name	DNA repair protein SWI5 homolog
Gene Name	SWI5
Organism	Homo sapiens (Human).
Sequence Length	235
Subcellular Localization	Nucleus.
Protein Description	Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination..
Protein Sequence	MQRRGQRDLWRHNKSCARNRCPRPPRERGGAGFPWVRAQLSVRQFTLRVRVPGPVHLRGRSPTPALDPLAPLNPLIRGPRTPGLRRWIQSLALLLPNCSSSRIPTVPRPHSGLWVQSDFPLGFLSRTEPRLTRSCRGAFRSPRPLPKSGQADGTSEESLHLDIQKLKEKRDMLDKEISQFVSEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKELYPEFGLDMND

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	QLSVRQFTLRVRVPG EEEEEEEEEEEECCC	12.81	24719451
61	Phosphorylation	PVHLRGRSPTPALDP CEEECCCCCCCCCCC	35.63	24719451
63	Phosphorylation	HLRGRSPTPALDPLA EECCCCCCCCCCCCC	23.57	24719451
134	Phosphorylation	TEPRLTRSCRGAFRS CCCCCCHHCCCCCCC	11.70	-
141	Phosphorylation	SCRGAFRSPRPLPKS HCCCCCCCCCCCCCC	20.86	29214152
148	Phosphorylation	SPRPLPKSGQADGTS CCCCCCCCCCCCCCC	33.91	25159151
223	Trimethylation	VIRGVTTKELYPEFG HHCCCCHHHHCHHHC	36.03	-
223	Methylation	VIRGVTTKELYPEFG HHCCCCHHHHCHHHC	36.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SWI5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SWI5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SWI5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SFR1_HUMAN	SFR1	physical	21252223
RAD51_HUMAN	RAD51	physical	21252223

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SWI5_HUMAN

Related Literatures of Post-Translational Modification