dbPTM

SFR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SFR1_HUMAN
UniProt AC	Q86XK3
Protein Name	Swi5-dependent recombination DNA repair protein 1 homolog
Gene Name	SFR1
Organism	Homo sapiens (Human).
Sequence Length	245
Subcellular Localization	Nucleus . Colocalizes with ESR1 in the nucleus.
Protein Description	Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. [PubMed: 21252223 Acts as a transcriptional modulator for ESR1]
Protein Sequence	MAEGEKNQDFTFKMESPSDSAVVLPSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLEFQESFKHIDSEFEENTNLKNTLKNLNVCESQSLDSGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVSEENKKLSLTQLIDHYGLDDKLLHYNRSEEEFIDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 3)	Acetylation	-	7.46	22814378
11	Phosphorylation	GEKNQDFTFKMESPS CCCCCCCEEEECCCC	30.54	20068231
16	Phosphorylation	DFTFKMESPSDSAVV CCEEEECCCCCCEEE	26.63	20068231
18	Phosphorylation	TFKMESPSDSAVVLP EEEECCCCCCEEECC	54.18	20068231
20	Phosphorylation	KMESPSDSAVVLPST EECCCCCCEEECCCC	27.57	26074081
23 (in isoform 2)	Phosphorylation	-	6.95	-
26	Phosphorylation	DSAVVLPSTPQASAN CCEEECCCCCCCCCC	48.86	26074081
27	Phosphorylation	SAVVLPSTPQASANP CEEECCCCCCCCCCC	19.92	26074081
31	Ubiquitination	LPSTPQASANPSSPY CCCCCCCCCCCCCCC	24.27	29967540
31	Phosphorylation	LPSTPQASANPSSPY CCCCCCCCCCCCCCC	24.27	26074081
35	Phosphorylation	PQASANPSSPYTNSS CCCCCCCCCCCCCCC	43.69	28985074
36	Phosphorylation	QASANPSSPYTNSSR CCCCCCCCCCCCCCC	24.15	25159151
38	Phosphorylation	SANPSSPYTNSSRKQ CCCCCCCCCCCCCCC	22.09	26074081
39	Phosphorylation	ANPSSPYTNSSRKQP CCCCCCCCCCCCCCC	31.82	26074081
41	Phosphorylation	PSSPYTNSSRKQPMS CCCCCCCCCCCCCCC	24.58	26074081
42	Phosphorylation	SSPYTNSSRKQPMSA CCCCCCCCCCCCCCH	45.63	20068231
44	Ubiquitination	PYTNSSRKQPMSATL CCCCCCCCCCCCHHH	61.78	29967540
48	Phosphorylation	SSRKQPMSATLRERL CCCCCCCCHHHHHHH	25.45	21815630
50	Phosphorylation	RKQPMSATLRERLRK CCCCCCHHHHHHHHH	21.02	29396449
58	Phosphorylation	LRERLRKTRFSFNSS HHHHHHHHHCCCCCC	30.43	28450419
61	Phosphorylation	RLRKTRFSFNSSYNV HHHHHHCCCCCCCCH	21.89	25159151
64	Phosphorylation	KTRFSFNSSYNVVKR HHHCCCCCCCCHHHH	31.99	29214152
65	Phosphorylation	TRFSFNSSYNVVKRL HHCCCCCCCCHHHHE	23.10	25159151
66	Phosphorylation	RFSFNSSYNVVKRLK HCCCCCCCCHHHHEE	16.28	29449344
70	Acetylation	NSSYNVVKRLKVESE CCCCCHHHHEEECCC	47.97	25953088
78 (in isoform 2)	Phosphorylation	-	75.32	25159151
90	Phosphorylation	FSEKPASSTEENCLE CCCCCCCCCHHHHHH	41.78	28450419
91	Phosphorylation	SEKPASSTEENCLEF CCCCCCCCHHHHHHH	44.84	28450419
101	Phosphorylation	NCLEFQESFKHIDSE HHHHHHHHHHHCCHH	28.89	28450419
103	Ubiquitination	LEFQESFKHIDSEFE HHHHHHHHHCCHHHH	49.26	22817900
107	Phosphorylation	ESFKHIDSEFEENTN HHHHHCCHHHHHCCC	43.51	25159151
107	Ubiquitination	ESFKHIDSEFEENTN HHHHHCCHHHHHCCC	43.51	22817900
116	Ubiquitination	FEENTNLKNTLKNLN HHHCCCHHHHHHHCC	50.37	22817900
120	Ubiquitination	TNLKNTLKNLNVCES CCHHHHHHHCCCCCC	58.30	22817900
153	Ubiquitination	KLPKQRLNAEKAKLV CCCHHHCCHHHHHHH	48.52	29967540
166	Ubiquitination	LVKQVQEKEDLLRRL HHHHHHHHHHHHHHH	39.16	29967540
178	Ubiquitination	RRLKLVKMYRSKNDL HHHHHHHHHCCCCCH	2.34	22817900
182	Ubiquitination	LVKMYRSKNDLSQLQ HHHHHCCCCCHHHHH	45.54	22817900
203	Ubiquitination	RSCSQLLLYELQSAV CCHHHHHHHHHHHHC	4.20	29967540
215	Acetylation	SAVSEENKKLSLTQL HHCCHHHHHCCHHHH	59.37	25953088
216	Ubiquitination	AVSEENKKLSLTQLI HCCHHHHHCCHHHHH	55.69	29967540
218	Phosphorylation	SEENKKLSLTQLIDH CHHHHHCCHHHHHHH	37.95	18767875

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SFR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SFR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SFR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SWI5_HUMAN	SWI5	physical	21252223
RAD51_HUMAN	RAD51	physical	21252223

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SFR1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.	19690332 [Abstract]