| UniProt ID | SV2B_HUMAN | |
|---|---|---|
| UniProt AC | Q7L1I2 | |
| Protein Name | Synaptic vesicle glycoprotein 2B | |
| Gene Name | SV2B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 683 | |
| Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, acrosome . Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secre |
|
| Protein Description | Probably plays a role in the control of regulated secretion in neural and endocrine cells.. | |
| Protein Sequence | MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MDDYKYQDNYGGY --CCCCCCCCCCCCC | 18.18 | - | |
| 10 | Phosphorylation | DYKYQDNYGGYAPSD CCCCCCCCCCCCCCC | 21.88 | - | |
| 13 | Phosphorylation | YQDNYGGYAPSDGYY CCCCCCCCCCCCCCC | 15.81 | 22817900 | |
| 19 | Phosphorylation | GYAPSDGYYRGNESN CCCCCCCCCCCCCCC | 8.59 | - | |
| 20 | Phosphorylation | YAPSDGYYRGNESNP CCCCCCCCCCCCCCH | 19.99 | 22817900 | |
| 25 | Phosphorylation | GYYRGNESNPEEDAQ CCCCCCCCCHHHHHC | 62.78 | 19845377 | |
| 33 | Phosphorylation | NPEEDAQSDVTEGHD CHHHHHCCCCCCCCC | 35.45 | 26657352 | |
| 36 | Phosphorylation | EDAQSDVTEGHDEED HHHCCCCCCCCCCCC | 41.04 | 26657352 | |
| 73 | Phosphorylation | MAPSRMDSLRGQTDL HCCHHHHHHCCCHHH | 15.60 | 25954137 | |
| 130 | Phosphorylation | GVEVFVVSFALPSAE CEEEEEEEEECCCCC | 10.25 | 26074081 | |
| 177 | Ubiquitination | DKLGRKRVLSMSLAV HHHCCCHHHHHHHHH | 5.35 | 30230243 | |
| 182 | Ubiquitination | KRVLSMSLAVNASFA CHHHHHHHHHCHHHH | 4.64 | 30230243 | |
| 185 | Ubiquitination | LSMSLAVNASFASLS HHHHHHHCHHHHHHH | 25.02 | 30230243 | |
| 190 | Ubiquitination | AVNASFASLSSFVQG HHCHHHHHHHHHHHH | 27.12 | 32142685 | |
| 198 | Ubiquitination | LSSFVQGYGAFLFCR HHHHHHHCHHHHHHH | 6.54 | 32142685 | |
| 208 | Phosphorylation | FLFCRLISGIGIGGA HHHHHHHHCCCCCCH | 29.02 | - | |
| 217 | Ubiquitination | IGIGGALPIVFAYFS CCCCCHHHHHHHHHH | 21.84 | 30230243 | |
| 222 | Ubiquitination | ALPIVFAYFSEFLSR HHHHHHHHHHHHHCH | 9.00 | 30230243 | |
| 230 | Ubiquitination | FSEFLSREKRGEHLS HHHHHCHHHHCCCCH | 43.67 | 32142685 | |
| 328 | Ubiquitination | HDTNMRAKGTPEKVF HHHCCCCCCCCCCEE | 53.61 | 30230243 | |
| 333 | Ubiquitination | RAKGTPEKVFTVSNI CCCCCCCCEEEECCC | 43.80 | 30230243 | |
| 341 | Ubiquitination | VFTVSNIKTPKQMDE EEEECCCCCHHHHHH | 64.13 | 32142685 | |
| 342 | Phosphorylation | FTVSNIKTPKQMDEF EEECCCCCHHHHHHH | 31.74 | 24076635 | |
| 417 | Phosphorylation | WFPDMIRYFQDEEYK HCHHHHHHHCCHHHH | 8.48 | 27196784 | |
| 423 | Phosphorylation | RYFQDEEYKSKMKVF HHHCCHHHHHHCEEE | 20.65 | 22817900 | |
| 441 | N-linked_Glycosylation | HVYGATINFTMENQI HHHCCEEEEEECCCH | 23.21 | UniProtKB CARBOHYD | |
| 491 | N-linked_Glycosylation | STDTYFKNCTIESTI CCCCCCCCCEEEEEE | 20.47 | UniProtKB CARBOHYD | |
| 516 | N-linked_Glycosylation | FINCRFINSTFLEQK EEEEEECCCHHCCCC | 32.08 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SV2B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SV2B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SV2B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HSFY1_HUMAN | HSFY1 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
