SUWA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUWA_DROME
• UniProt AC: P12297
• Protein Name: Protein suppressor of white apricot
• Gene Name: su(w[a])
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 963
• Subcellular Localization: Nucleus speckle. Speckled subnuclear compartment.
• Protein Description: Regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). Regulate its own expression at the level of RNA processing..
• Protein Sequence: MLPYNVRNAGGGSVGGILRRTGQGSGTGSTILGNGNSPGALGAGKVSSSLENHRQPPLELLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAPPGGYGNRLEYLSAEEQRAEQLCEEERYLFLYNNEEELRLRQEEDLKRLQQETSGGCFSQVGFQYDGQSAASTSIGGSSTATSQLSPNSEESELPFVLPYTLMMAPPLDMQLPETMKQHAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIKAAKFPPAPQTPLDQQNTDKEAPSADDHSEEVAGGRRNPNQVVITVPTIKYKPSANCAYTQLISKIKGVPLQAVLQEDESSNPGNSQHSGGTASPALSCRSEGHNSQGGEFTPVLLQYNGSTFTHEEESSNREQQDDNDVNGGEPPQVELLKNTSALALAQNYSSESEEEEDQVQPEKEEEKKPEPVLTFPVPKDSLRHIIDKTATYVIKNGRQFEETLRTKSVDRFSFLLPANEYYPYYLYKVTGDVDAASKEEKTRKAAAVAAALMSKKGLSFGGAAAAVSGSNLDKAPVSFSIRARDDQCPLQHTLPQEASDEETSSNAAGVEHVRPGMPDSVQRAIKQVETQLLARTAGQKGNITASPSCSSPQKEQRQAEERVKDKLAQIAREKLNGMISREKQLQLERKRKALAFLNQIKGEGAIVGSAVPVVGPNPPESAAGAATADSGDESGDSVRSIPITYFGPDDDDEVGEQRPEMRLIGSTQKDEEDDDEEDGGDLEKYNLLNDDSTNTFTSKPVLPPTAAPPPAAVLLSDDDDVQLVATTSTRSSSSRHLKTHRRSRSRSKNVRSSDSSPSSRESSRRRRQKSSRLSREPSSNPPRKSQHSSTQRKKTPKKRRRSKSRSRSKSIRRSRSISILRNNRRSRSRSPSCRNAEQRRQQDRRRTPTKKSHKRHKRRRRSSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
364	Phosphorylation	VLQEDESSNPGNSQH EEECCCCCCCCCCCC	45.02	21082442
437	Phosphorylation	QVELLKNTSALALAQ HHHHHHHHHHHHHHH	17.50	19429919
438	Phosphorylation	VELLKNTSALALAQN HHHHHHHHHHHHHHH	30.58	19429919
446	Phosphorylation	ALALAQNYSSESEEE HHHHHHHCCCCCHHH	11.07	19429919
447	Phosphorylation	LALAQNYSSESEEEE HHHHHHCCCCCHHHH	34.87	19429919
448	Phosphorylation	ALAQNYSSESEEEED HHHHHCCCCCHHHHH	34.48	19429919
450	Phosphorylation	AQNYSSESEEEEDQV HHHCCCCCHHHHHCC	52.86	19429919
597	Phosphorylation	HTLPQEASDEETSSN CCCCCCCCCCCCCCC	44.81	22668510
649	Phosphorylation	TASPSCSSPQKEQRQ CCCCCCCCHHHHHHH	35.36	19060867
678	Phosphorylation	EKLNGMISREKQLQL HHHHHHCCHHHHHHH	26.04	27626673
738	Phosphorylation	ESGDSVRSIPITYFG CCCCCCCEEEEEEEC	30.47	19429919
742	Phosphorylation	SVRSIPITYFGPDDD CCCEEEEEEECCCCC	13.88	19429919
872	Phosphorylation	RQKSSRLSREPSSNP HHHHHHHCCCCCCCC	33.22	22817900
912	Phosphorylation	RSKSIRRSRSISILR HCHHHHHHHHHHHHC	22.11	25749252
914	Phosphorylation	KSIRRSRSISILRNN HHHHHHHHHHHHCCC	23.18	25749252
916	Phosphorylation	IRRSRSISILRNNRR HHHHHHHHHHCCCCC	19.47	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUWA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUWA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUWA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CFA20_DROME	CG5343	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; SER-447; SER-448;SER-450; SER-649; SER-912; SER-914 AND SER-916, AND MASS SPECTROMETRY.
PubMed: 18327897