SUN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUN5_HUMAN
• UniProt AC: Q8TC36
• Protein Name: SUN domain-containing protein 5
• Gene Name: SUN5
• Organism: Homo sapiens (Human).
• Sequence Length: 379
• Subcellular Localization: Nucleus inner membrane ; Single-pass membrane protein . Golgi apparatus . During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling appara
• Protein Description: Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope..
• Protein Sequence: MPRSSRSPGDPGALLEDVAHNPRPRRIAQRGRNTSRMAEDTSPNMNDNILLPVRNNDQALGLTQCMLGCVSWFTCFACSLRTQAQQVLFNTCRCKLLCQKLMEKTGILLLCAFGFWMFSIHLPSKMKVWQDDSINGPLQSLRLYQEKVRHHSGEIQDLRGSMNQLIAKLQEMEAMSDEQKMAQKIMKMIHGDYIEKPDFALKSIGASIDFEHTSVTYNHEKAHSYWNWIQLWNYAQPPDVILEPNVTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTISLSGSLDTAPKDFVIYGMEGSPKEEVFLGAFQFQPENIIQMFPLQNQPARAFSAVKVKISSNWGNPGFTCLYRVRVHGSVAPPREQPHQNPYPKRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPRSSRSPGDP ----CCCCCCCCCCC	25.00	22210691
5	Phosphorylation	---MPRSSRSPGDPG ---CCCCCCCCCCCC	37.75	22210691
7	Phosphorylation	-MPRSSRSPGDPGAL -CCCCCCCCCCCCCC	34.87	22210691
124	Phosphorylation	MFSIHLPSKMKVWQD HHEECCCCCCCCCCC	52.31	24719451
180	Ubiquitination	EAMSDEQKMAQKIMK HCCCHHHHHHHHHHH	33.87	-
262	Phosphorylation	EGDRGQVTIQLAQKV ECCCCEEEEECCHHH	8.63	25003641
343	Phosphorylation	SAVKVKISSNWGNPG EEEEEEEECCCCCCC	16.35	-
344	Phosphorylation	AVKVKISSNWGNPGF EEEEEEECCCCCCCE	39.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUN5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUN5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.