STX4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX4_RAT
• UniProt AC: Q08850
• Protein Name: Syntaxin-4
• Gene Name: Stx4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 298
• Subcellular Localization: Cell membrane ; Single-pass type IV membrane protein .
• Protein Description: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones..
• Protein Sequence: MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLSSPDDEFFQKVQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLKAIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERTIRELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMIAICVSVTVLILAVIIGITITVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRDRTHELRQGD ---CCCCCCCCCCCC	24.80	23984901
15	Phosphorylation	LRQGDNISDDEDEVR CCCCCCCCCCCCHHH	45.31	23712012
29	Phosphorylation	RVALVVHSGAARLSS HEEEEEECCCCCCCC	20.65	23984901
35	Phosphorylation	HSGAARLSSPDDEFF ECCCCCCCCCCHHHH	33.98	23298284
36	Phosphorylation	SGAARLSSPDDEFFQ CCCCCCCCCCHHHHH	36.62	23298284
54	Acetylation	TIRQTMAKLESKVRE HHHHHHHHHHHHHHH	41.80	22902405
115	Phosphorylation	KEEADENYNSVNTRM HHHCCCCCHHHHHHH	13.53	23298284
117	Phosphorylation	EADENYNSVNTRMKK HCCCCCHHHHHHHHH	13.34	23712012
120	Phosphorylation	ENYNSVNTRMKKTQH CCCHHHHHHHHHHHC	29.95	27097102
204	Phosphorylation	RQALNEISARHSEIQ HHHHHHHHHHHHHHH	17.05	25575281
208	Phosphorylation	NEISARHSEIQQLER HHHHHHHHHHHHHHH	30.73	29779826
247	Phosphorylation	RIEKNILSSADYVER HHHHHHHCCCHHHHH	21.49	30181290
248	Phosphorylation	IEKNILSSADYVERG HHHHHHCCCHHHHHC	23.01	27097102
251	Phosphorylation	NILSSADYVERGQEH HHHCCCHHHHHCHHH	12.15	21940666

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STX4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNP25_MOUSE	Snap25	physical	7768895
STXB1_RAT	Stxbp1	physical	7768895

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.