STX1B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX1B_RAT
• UniProt AC: P61265
• Protein Name: Syntaxin-1B
• Gene Name: Stx1b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 288
• Subcellular Localization: Membrane ; Single-pass type IV membrane protein .
• Protein Description: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)..
• Protein Sequence: MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTLGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DRTQELRSAKDSDDE HHHHHHHHCCCCCCH	52.90	25403869
14	Phosphorylation	ELRSAKDSDDEEEVV HHHHCCCCCCHHHEE	46.37	30411139
45	Ubiquitination	EIRGCIEKLSEDVEQ HHHHHHHHHHHHHHH	37.08	-
54	Acetylation	SEDVEQVKKQHSAIL HHHHHHHHHHHHHHH	46.54	22902405
55	Ubiquitination	EDVEQVKKQHSAILA HHHHHHHHHHHHHHH	55.15	-
58	Phosphorylation	EQVKKQHSAILAAPN HHHHHHHHHHHHCCC	17.95	25403869
69	Ubiquitination	AAPNPDEKTKQELED HCCCCCHHHHHHHHH	69.29	-
71	Acetylation	PNPDEKTKQELEDLT CCCCHHHHHHHHHHH	53.49	22902405
82	Acetylation	EDLTADIKKTANKVR HHHHHHHHHHHHHHH	44.62	22902405
91	Acetylation	TANKVRSKLKAIEQS HHHHHHHHHHHHHHH	43.36	22902405
93	Acetylation	NKVRSKLKAIEQSIE HHHHHHHHHHHHHHH	51.56	22902405
93	Ubiquitination	NKVRSKLKAIEQSIE HHHHHHHHHHHHHHH	51.56	-
121	Phosphorylation	IRKTQHSTLSRKFVE HHHHHCCHHHHHHHH	26.99	25403869
125	Ubiquitination	QHSTLSRKFVEVMTE HCCHHHHHHHHHHHH	50.84	-
139	Acetylation	EYNATQSKYRDRCKD HCCCCHHHHHHHHHH	34.19	22902405
139	Ubiquitination	EYNATQSKYRDRCKD HCCCCHHHHHHHHHH	34.19	-
158	Phosphorylation	QLEITGRTTTNEELE HHHHHCCCCCHHHHH	39.04	22673903
159	Phosphorylation	LEITGRTTTNEELED HHHHCCCCCHHHHHH	26.68	22673903
160	Phosphorylation	EITGRTTTNEELEDM HHHCCCCCHHHHHHH	39.77	25403869
172	Ubiquitination	EDMLESGKLAIFTDD HHHHHHCCEEEECCC	43.98	-
181	Ubiquitination	AIFTDDIKMDSQMTK EEECCCCCCCHHHHH	43.58	-
188	Ubiquitination	KMDSQMTKQALNEIE CCCHHHHHHHHHHHH	28.38	-
203	Ubiquitination	TRHNEIIKLETSIRE HHHHHHHHHHHHHHH	46.03	-
255	Ubiquitination	SDTKKAVKYQSKARR HHHHHHHHHHCHHHH	42.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
14	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX1B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX1B_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STXB1_RAT	Stxbp1	physical	8108429

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A method for the comprehensive proteomic analysis of membraneproteins.";
Wu C.C., MacCoss M.J., Howell K.E., Yates J.R. III;
Nat. Biotechnol. 21:532-538(2003).
Cited for: PHOSPHORYLATION AT SER-14.
PubMed: 12692561