STOX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STOX1_HUMAN
• UniProt AC: Q6ZVD7
• Protein Name: Storkhead-box protein 1
• Gene Name: STOX1
• Organism: Homo sapiens (Human).
• Sequence Length: 989
• Subcellular Localization: Isoform A: Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosom
• Protein Description: Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. [PubMed: 24738702 Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity; Isoform A: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry]
• Protein Sequence: MARPVQLAPGSLALVLCRLEAQKAAGAAEEPGGRAVFRAFRRANARCFWNARLARAASRLAFQGWLRRGVLLVRAPPACLQVLRDAWRRRALRPPRGFRIRAVGDVFPVQMNPITQSQFVPLGEVLCCAISDMNTAQIVVTQESLLERLMKHYPGIAIPSEDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTTQENKRMLPSDESRLMPASMTYLVSMESCAESAQENAAPISHCQSCQCFRDMHTQDVQEAPVAAEVTRKSHRGLGESVSWVQNGAVSVSAEHHICESTKPLPYTRDKEKGKKFGFSLLWRSLSRKEKPKTEHSSFSAQFPPEEWPVRDEDDLDNIPRDVEHEIIKRINPILTVDNLIKHTVLMQKYEEQKKYNSQGTSTDMLTIGHKYPSKEGVKKRQGLSAKPQGQGHSRRDRHKARNQGSEFQPGSIRLEKHPKLPATQPIPRIKSPNEMVGQKPLGEITTVLGSHLIYKKRISNPFQGLSHRGSTISKGHKIQKTSDLKPSQTGPKEKPFQKPRSLDSSRIFDGKAKEPYAEQPNDKMEAESIYINDPTVKPINDDFRGHLFSHPQQSMLQNDGKCCPFMESMLRYEVYGGENEVIPEVLRKSHSHFDKLGETKQTPHSLPSRGASFSDRTPSACRLVDNTIHQFQNLGLLDYPVGVNPLRQAARQDKDSEELLRKGFVQDAETTSLENEQLSNDDQALYQNEVEDDDGACSSLYLEEDDISENDDLRQMLPGHSQYSFTGGSQGNHLGKQKVIERSLTEYNSTMERVESQVLKRNECYKPTGLHATPGESQEPNLSAESCGLNSGAQFGFNYEEEPSVAKCVQASAPADERIFDYYSARKASFEAEVIQDTIGDTGKKPASWSQSPQNQEMRKHFPQKFQLFNTSHMPVLAQDVQYEHSHLEGTENHSMAGDSGIDSPRTQSLGSNNSVILDGLKRRQNFLQNVEGTKSSQPLTSNSLLPLTPVINV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	LCRLEAQKAAGAAEE HHHHHHHHHCCCCCC	47.45	22817900
23 (in isoform 3)	Ubiquitination	-	47.45	21906983
23 (in isoform 2)	Ubiquitination	-	47.45	21906983
23 (in isoform 1)	Ubiquitination	-	47.45	21906983
223	Phosphorylation	ASMTYLVSMESCAES HHHHHHCCHHHHHHH	17.78	22210691
314	Phosphorylation	KGKKFGFSLLWRSLS HCCHHCHHHHHHHCC	23.96	-
321	Phosphorylation	SLLWRSLSRKEKPKT HHHHHHCCCCCCCCC	42.42	24260401
363	Ubiquitination	DVEHEIIKRINPILT CHHHHHHHHHCCCEE	53.54	29967540
370	Phosphorylation	KRINPILTVDNLIKH HHHCCCEEHHHHHHH	26.91	-
390	Phosphorylation	KYEEQKKYNSQGTST HHHHHHHHCCCCCCC	27.38	22210691
392	Phosphorylation	EEQKKYNSQGTSTDM HHHHHHCCCCCCCCC	27.22	22210691
395	Phosphorylation	KKYNSQGTSTDMLTI HHHCCCCCCCCCEEC	22.33	22210691
396	Phosphorylation	KYNSQGTSTDMLTIG HHCCCCCCCCCEECC	29.27	22210691
397	Phosphorylation	YNSQGTSTDMLTIGH HCCCCCCCCCEECCC	25.85	22210691
406	Phosphorylation	MLTIGHKYPSKEGVK CEECCCCCCCCCCCC	13.68	26074081
408	Phosphorylation	TIGHKYPSKEGVKKR ECCCCCCCCCCCCCC	40.00	26074081
428	Phosphorylation	KPQGQGHSRRDRHKA CCCCCCCCHHHHHHH	35.52	-
434	Ubiquitination	HSRRDRHKARNQGSE CCHHHHHHHHHCCCC	50.35	-
458	Phosphorylation	KHPKLPATQPIPRIK CCCCCCCCCCCCCCC	32.70	23312004
466	Phosphorylation	QPIPRIKSPNEMVGQ CCCCCCCCCCCCCCC	30.50	-
517	Phosphorylation	GHKIQKTSDLKPSQT CCCCEECCCCCCCCC	48.24	-
527	Ubiquitination	KPSQTGPKEKPFQKP CCCCCCCCCCCCCCC	78.64	29967540
565	Phosphorylation	KMEAESIYINDPTVK CCEEEEEEECCCCCC	11.71	27642862
607	Phosphorylation	FMESMLRYEVYGGEN HHHHHHHEEECCCCC	13.04	22817900
610	Phosphorylation	SMLRYEVYGGENEVI HHHHEEECCCCCCCH	13.89	22817900
624	Phosphorylation	IPEVLRKSHSHFDKL HHHHHHHCHHCHHHC	24.64	24144214
626	Phosphorylation	EVLRKSHSHFDKLGE HHHHHCHHCHHHCCC	32.70	24144214
630	Ubiquitination	KSHSHFDKLGETKQT HCHHCHHHCCCCCCC	58.40	29967540
634	Phosphorylation	HFDKLGETKQTPHSL CHHHCCCCCCCCCCC	27.01	24144214
637	Phosphorylation	KLGETKQTPHSLPSR HCCCCCCCCCCCCCC	25.23	24144214
640	Phosphorylation	ETKQTPHSLPSRGAS CCCCCCCCCCCCCCC	43.08	24144214
643	Phosphorylation	QTPHSLPSRGASFSD CCCCCCCCCCCCCCC	48.95	24144214
647	Phosphorylation	SLPSRGASFSDRTPS CCCCCCCCCCCCCHH	28.27	24719451
743	Phosphorylation	YLEEDDISENDDLRQ EECCCCCCCCCCHHH	37.02	-
782	Phosphorylation	IERSLTEYNSTMERV HHHHHHHHHHHHHHH	14.80	27642862
785	Phosphorylation	SLTEYNSTMERVESQ HHHHHHHHHHHHHHH	21.29	27642862
791	Phosphorylation	STMERVESQVLKRNE HHHHHHHHHHHHCCC	23.80	-
857	Phosphorylation	ADERIFDYYSARKAS CCHHHHHHHHHHHHH	6.64	27642862
858	Phosphorylation	DERIFDYYSARKASF CHHHHHHHHHHHHHC	9.56	27642862
864	Phosphorylation	YYSARKASFEAEVIQ HHHHHHHHCEEEEEH	27.01	27050516
977	Phosphorylation	KSSQPLTSNSLLPLT CCCCCCCCCCCCCCC	31.91	24719451
979	Phosphorylation	SQPLTSNSLLPLTPV CCCCCCCCCCCCCCC	30.93	24719451
984	Phosphorylation	SNSLLPLTPVINV-- CCCCCCCCCCCCC--	17.36	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STOX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STOX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STOX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPM2_HUMAN	TPM2	physical	28514442
DPP9_HUMAN	DPP9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609404: Pre-eclampsia/eclampsia 4 (PEE4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.