STML3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STML3_MOUSE
• UniProt AC: Q6PE84
• Protein Name: Stomatin-like protein 3
• Gene Name: Stoml3
• Organism: Mus musculus (Mouse).
• Sequence Length: 287
• Subcellular Localization: Cell membrane ; Single-pass type III membrane protein . Detected in lipid rafts, in apical dendrites and in olfactory cilia.
• Protein Description: Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations..
• Protein Sequence: MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGISYGNNKKVTAKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSPEKLEKN -----CCCHHHHHHC	33.39	-
237	Phosphorylation	ASMVLAESPVALQLR HHHHHHCCHHHHHHH	21.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STML3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STML3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STML3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAV1_MOUSE	Cav1	physical	12122055
ADCY3_MOUSE	Adcy3	physical	12122055

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.