ADCY3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCY3_MOUSE
• UniProt AC: Q8VHH7
• Protein Name: Adenylate cyclase type 3
• Gene Name: Adcy3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1145
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, cilium . Golgi apparatus . Cytoplasm .
• Protein Description: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. [PubMed: 9768837]
• Protein Sequence: MPRNQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGFGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLISAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSAVPNGAPASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRSFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNMTAGMELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTALNLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTLPHQVVDNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	S-palmitoylation	SVRNSGSCLCLPRFM EEECCCCEEEECCHH	3.38	28680068
48	S-palmitoylation	RNSGSCLCLPRFMRL ECCCCEEEECCHHHE	6.04	28680068
293	Ubiquitination	HVADEMLKDMKKDES HHHHHHHHHHCCCCH	55.24	-
297	Ubiquitination	EMLKDMKKDESQKDQ HHHHHHCCCCHHHHH	61.15	-
311	Phosphorylation	QQQFNTMYMYRHENV HHHHHHHHHHHCCCE	6.75	28576409
428	Ubiquitination	LGGVLGQKRWQYDVW HHCHHCCCCCEEEEE	54.53	-
436	Phosphorylation	RWQYDVWSTDVTVAN CCEEEEECCCEEEHH	17.99	27566939
460	Phosphorylation	RVHISQSTMDCLKGE EEEECHHHHHHHCCC	14.91	28285833
519	Phosphorylation	VPNGAPASSKPSSPA CCCCCCCCCCCCCCC	37.52	28285833
520	Phosphorylation	PNGAPASSKPSSPAL CCCCCCCCCCCCCCE	51.17	28285833
524	Phosphorylation	PASSKPSSPALIETK CCCCCCCCCCEEEEC	23.79	-
579	Phosphorylation	ADRVVDASEDEHELN HHHHCCCCCCHHHHH	40.91	26824392
735	N-linked_Glycosylation	QYYMGPYNMTAGMEL HHHHCCCCCCCCCEE	25.18	-
777	Phosphorylation	VSHMVKLTLMLLVTG HHHHHHHHHHHHHHH	12.38	25293948
783	Phosphorylation	LTLMLLVTGAVTALN HHHHHHHHHHHHHHH	21.28	25293948
787	Phosphorylation	LLVTGAVTALNLYAW HHHHHHHHHHHHHHH	25.54	25293948
792	Phosphorylation	AVTALNLYAWCPVFD HHHHHHHHHHCCCCC	9.29	25293948
801	Phosphorylation	WCPVFDEYDHKRFQE HCCCCCCCCHHHHHC	25.78	25293948
1047	Ubiquitination	MLRIGMNKGGVLAGV HHEECCCCCCCEEEE	48.42	-
1077	Phosphorylation	NVASRMESTGVMGNI EHHHHHHHCCCCCCE	22.55	22817900
1133	Phosphorylation	PAAFPNGSSVTLPHQ CCCCCCCCCCCCCCC	28.42	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1077	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
1077	S	Phosphorylation	Kinase	CAMK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1077	S	Phosphorylation	Phosphorylation by CaMK2 at Ser-1077 down-regulates enzyme activity.	9768837

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADCY3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STML3_MOUSE	Stoml3	physical	12122055
CAV1_MOUSE	Cav1	physical	12122055

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.