STEA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STEA1_HUMAN
• UniProt AC: Q9UHE8
• Protein Name: Metalloreductase STEAP1
• Gene Name: STEAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 339
• Subcellular Localization: Endosome membrane; Multi-pass membrane protein.
• Protein Description: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity)..
• Protein Sequence: MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	RNLEEDDYLHKDTGE CCCCCCCCCCCCCCC	24.03	21945579
30	Ubiquitination	EEDDYLHKDTGETSM CCCCCCCCCCCCCCC	55.16	33845483
39	Ubiquitination	TGETSMLKRPVLLHL CCCCCCCCCCHHHHH	46.12	29901268
83	Phosphorylation	KIAAIIASLTFLYTL HHHHHHHHHHHHHHH	19.96	22210691
160	Phosphorylation	WLDKWMLTRKQFGLL HHHHHHHHHHHHHHH	21.51	-
177	Ubiquitination	FFAVLHAIYSLSYPM HHHHHHHHHHCCCCC	1.35	21906983
178	Phosphorylation	FAVLHAIYSLSYPMR HHHHHHHHHCCCCCH	12.35	-
188	Phosphorylation	SYPMRRSYRYKLLNW CCCCHHHHHHHHHHH	19.02	-
219	Phosphorylation	DVWRMEIYVSLGIVG CHHHHHHHHHHHHHH	3.18	-
221	Phosphorylation	WRMEIYVSLGIVGLA HHHHHHHHHHHHHHH	12.14	-
329	Ubiquitination	HGWEDVTKINKTEIC CCCCCCHHCCHHHHH	44.10	33845483
332	Ubiquitination	EDVTKINKTEICSQL CCCHHCCHHHHHCCC	51.51	33845483
337	Phosphorylation	INKTEICSQL----- CCHHHHHCCC-----	39.93	22617229
476	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------		21906983
479	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------		21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STEA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STEA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STEA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOLP3_HUMAN	GOLPH3	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.