STAU1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAU1_MOUSE
• UniProt AC: Q9Z108
• Protein Name: Double-stranded RNA-binding protein Staufen homolog 1
• Gene Name: Stau1
• Organism: Mus musculus (Mouse).
• Sequence Length: 487
• Subcellular Localization: Cytoplasm. Rough endoplasmic reticulum. Localizes exclusively with the rough reticulum endoplasmic (RER).
• Protein Description: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site..
• Protein Sequence: MYKPVDPHSRMQSTYSYGMRGGAYPPRYFYPFPVPPLLYQVELSVGGQQFNGKGKMRPPVKHDAPARALRTLQSEPLPERLEVNGREAEEENLNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTRVSVGEFVGEGEGKSKKISKKNAARAVLEQLRRLPPLPAVERVKPRIKKKSQPTCKTAPDYGQGMNPISRLAQIQQAKKEKEPEYMLLTERGLPRRREFVMQVKVGHHTAEGVGTNKKVAKRNAAENMLEILGFKVPQAQPAKPALKSEEKTPVKKPGDGRKVTFFEPSPGDENGTSNKDEEFRMPYLSHQQLPAGILPMVPEVAQAVGVSQGHHTKDFTRAAPNPAKATVTAMIARELLYGGTSPTAETILKSNISSGHVPHGPRTRPSEQLYYLSRAQGFQVEYKDFPKNNKNECVSLINCSSQPPLVSHGIGKDVESCHDMAALNILKLLSELDQQSTEMPRTGNGPVSACGRC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYKPVDPHS ------CCCCCCCCH	24.81	29514104
20	Methylation	STYSYGMRGGAYPPR CCCCCCCCCCCCCCC	35.71	24129315
20	Asymmetric dimethylarginine	STYSYGMRGGAYPPR CCCCCCCCCCCCCCC	35.71	-
27	Asymmetric dimethylarginine	RGGAYPPRYFYPFPV CCCCCCCCCCCCCCC	29.68	-
27	Methylation	RGGAYPPRYFYPFPV CCCCCCCCCCCCCCC	29.68	24129315
282	Phosphorylation	ALKSEEKTPVKKPGD CCCCCCCCCCCCCCC	36.27	-
294	Phosphorylation	PGDGRKVTFFEPSPG CCCCCEEEEECCCCC	26.16	25168779
299	Phosphorylation	KVTFFEPSPGDENGT EEEEECCCCCCCCCC	34.03	25619855
306	Phosphorylation	SPGDENGTSNKDEEF CCCCCCCCCCCCCCC	40.48	25168779
307	Phosphorylation	PGDENGTSNKDEEFR CCCCCCCCCCCCCCC	43.19	25168779
371	Phosphorylation	MIARELLYGGTSPTA HHHHHHHHCCCCCCH	26.57	18563927
374	Phosphorylation	RELLYGGTSPTAETI HHHHHCCCCCCHHHH	27.46	28066266
375	Phosphorylation	ELLYGGTSPTAETIL HHHHCCCCCCHHHHH	24.43	28066266
377	Phosphorylation	LYGGTSPTAETILKS HHCCCCCCHHHHHHH	36.57	28066266
380	Phosphorylation	GTSPTAETILKSNIS CCCCCHHHHHHHCCC	29.19	28066266
404	Phosphorylation	TRPSEQLYYLSRAQG CCHHHHHHHHHHHCC	11.31	17242355
417	Ubiquitination	QGFQVEYKDFPKNNK CCCEEEECCCCCCCC	39.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAU1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAU1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAU1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCD_DROME	bcd	physical	10022909

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.