STAR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAR_HUMAN
• UniProt AC: P49675
• Protein Name: Steroidogenic acute regulatory protein, mitochondrial
• Gene Name: STAR
• Organism: Homo sapiens (Human).
• Sequence Length: 285
• Subcellular Localization: Mitochondrion.
• Protein Description: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone..
• Protein Sequence: MLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRALGGPTPSTWINQVRRRSSLLGSRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLLATFKLCAGS ---CCHHHHHHHCCC	22.67	26074081
12	Phosphorylation	TFKLCAGSSYRHMRN HHHHHCCCCHHHHHH	12.98	26074081
13	Phosphorylation	FKLCAGSSYRHMRNM HHHHCCCCHHHHHHC	25.85	26074081
14	Phosphorylation	KLCAGSSYRHMRNMK HHHCCCCHHHHHHCC	13.26	26074081
32	Phosphorylation	QQAVMAISQELNRRA HHHHHHHHHHHHHHH	14.20	26074081
56	Phosphorylation	INQVRRRSSLLGSRL HHHHHHHHHHHCHHH	24.43	-
57	Phosphorylation	NQVRRRSSLLGSRLE HHHHHHHHHHCHHHH	26.29	22817900
61	Phosphorylation	RRSSLLGSRLEETLY HHHHHHCHHHHHHHC	33.39	-
100	Phosphorylation	QEGWKKESQQDNGDK CCCHHHHHHCCCCCH	41.86	30619164
195	Phosphorylation	RCAKRRGSTCVLAGM EEHHHCCCEEEEEEE	19.47	9097960
204	Phosphorylation	CVLAGMATDFGNMPE EEEEEEECCCCCCCH	23.99	-
244	Phosphorylation	TKLTWLLSIDLKGWL CCEEEEEEEECCCCC	16.34	24961811
254	Phosphorylation	LKGWLPKSIINQVLS CCCCCCHHHHHHHHH	27.11	27174698
261	Phosphorylation	SIINQVLSQTQVDFA HHHHHHHHHHHHHHH	32.12	27174698
263	Phosphorylation	INQVLSQTQVDFANH HHHHHHHHHHHHHHH	27.47	27174698
273	Acetylation	DFANHLRKRLESHPA HHHHHHHHHHHHCCC	68.63	7704201

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
57	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
57	S	Phosphorylation	Kinase	PKA	-	Uniprot
195	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
195	S	Phosphorylation	Kinase	PKA	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUCB2_HUMAN	NUCB2	physical	12909641
CCHCR_HUMAN	CCHCR1	physical	12909641
FEZ1_HUMAN	FEZ1	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 201710: Adrenal hyperplasia 1 (AH1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The steroidogenic acute regulatory protein (StAR): a window into thecomplexities of intracellular cholesterol trafficking.";
Strauss J.F. III, Kallen C.B., Christenson L.K., Watari H., Devoto L.,Arakane F., Kiriakidou M., Sugawara T.;
Recent Prog. Horm. Res. 54:369-394(1999).
Cited for: PHOSPHORYLATION AT SER-57 AND SER-195.
PubMed: 10548884