STAM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAM2_MOUSE
• UniProt AC: O88811
• Protein Name: Signal transducing adapter molecule 2
• Gene Name: Stam2
• Organism: Mus musculus (Mouse).
• Sequence Length: 523
• Subcellular Localization: Cytoplasm . Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity)..
• Protein Sequence: MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPSGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRSVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGVTFPSAGSQTVAAAAKNGTSLNKNKEDEDIAKAIELSLQEQKQQYTETKALYPPAESQLNNKAARRVRALYDFEAVEDNELTFKHGELITVLDDSDANWWQGENHRGTGLFPSNFVTTDLSTEVETATVDKLNVIDDDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKESKPDSQDLLDLEDVCQQMGPMIDEKLEEIDRKHSELSELNVKVLEALDLYNKLVNEAPVYSVYSKLHPAHYPPAAAGVPVQTYPVQSHGGNYLGHGIHQVSVAQNYNLGPDPMGSLRSLPPNMNSVTAHTVQPPYLSTGQDTVSNPSYMNQSSRLQAAAGTAAYTQPVGMSTDVSSFQNTASGLPQLAGFPVAVPAPVAAQPQASYHQQPLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Ubiquitination	SLISATIKSMKEEGV HHHHHHHHHHHHHCC	39.89	22790023
156	Ubiquitination	QTVAAAAKNGTSLNK HHHHHHHHCCCCCCC	51.70	22790023
182	Ubiquitination	ELSLQEQKQQYTETK HHHHHHHHHHHHHHH	38.32	22790023
185	Phosphorylation	LQEQKQQYTETKALY HHHHHHHHHHHHCCC	12.21	29514104
189	Ubiquitination	KQQYTETKALYPPAE HHHHHHHHCCCCCHH	30.11	22790023
192	Phosphorylation	YTETKALYPPAESQL HHHHHCCCCCHHHHH	16.42	26026062
202	Ubiquitination	AESQLNNKAARRVRA HHHHHCHHHHHHHHH	42.20	22790023
284	Ubiquitination	DDVEEIKKSEPEPVY CCHHHHHHCCCCCEE	66.76	22790023
285	Phosphorylation	DVEEIKKSEPEPVYI CHHHHHHCCCCCEEE	54.07	25338131
343	Ubiquitination	KLEEIDRKHSELSEL HHHHHHHHCHHHHHH	47.97	-
363	Ubiquitination	EALDLYNKLVNEAPV HHHHHHHHHHCCCCC	40.01	-
371	Phosphorylation	LVNEAPVYSVYSKLH HHCCCCCHHHCCCCC	7.43	26032504
372	Phosphorylation	VNEAPVYSVYSKLHP HCCCCCHHHCCCCCC	18.14	25367039
374	Phosphorylation	EAPVYSVYSKLHPAH CCCCHHHCCCCCCCC	8.31	20116462
375	Phosphorylation	APVYSVYSKLHPAHY CCCHHHCCCCCCCCC	26.95	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAM2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAM2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	12972556
GBG12_MOUSE	Gng12	physical	20697350
HGS_MOUSE	Hgs	physical	20697350
ALDOA_MOUSE	Aldoa	physical	20697350
CRK_MOUSE	Crk	physical	20697350
UBC_MOUSE	Ubc	physical	16432517

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-374, AND MASSSPECTROMETRY.
PubMed: 15592455