GBG12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBG12_MOUSE
• UniProt AC: Q9DAS9
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
• Gene Name: Gng12
• Organism: Mus musculus (Mouse).
• Sequence Length: 72
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MSSKTASTNSIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLMGIPTSENPFKDKKTCIIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSKTASTN ------CCCCCCCHH	40.31	7493986
2	Acetylation	------MSSKTASTN ------CCCCCCCHH	40.31	-
3	Phosphorylation	-----MSSKTASTNS -----CCCCCCCHHH	32.50	25266776
4	Ubiquitination	----MSSKTASTNSI ----CCCCCCCHHHH	40.58	-
4	Succinylation	----MSSKTASTNSI ----CCCCCCCHHHH	40.58	23806337
4	Acetylation	----MSSKTASTNSI ----CCCCCCCHHHH	40.58	23806337
5	Phosphorylation	---MSSKTASTNSIA ---CCCCCCCHHHHH	27.99	25521595
7	Phosphorylation	-MSSKTASTNSIAQA -CCCCCCCHHHHHHH	33.09	25521595
8	Phosphorylation	MSSKTASTNSIAQAR CCCCCCCHHHHHHHH	30.44	25521595
10	Phosphorylation	SKTASTNSIAQARRT CCCCCHHHHHHHHHH	21.27	25521595
26	Phosphorylation	QQLRLEASIERIKVS HHHHHHHHHHHHHHC	18.66	26824392
34	Ubiquitination	IERIKVSKASADLMS HHHHHHCHHHHHHHH	49.72	22790023
36	Phosphorylation	RIKVSKASADLMSYC HHHHCHHHHHHHHHH	26.50	26745281
41	Phosphorylation	KASADLMSYCEEHAR HHHHHHHHHHHHHHH	33.65	26745281
42	Phosphorylation	ASADLMSYCEEHARS HHHHHHHHHHHHHHC	7.01	26745281
43	S-nitrosylation	SADLMSYCEEHARSD HHHHHHHHHHHHHCC	3.77	21278135
43	S-nitrosocysteine	SADLMSYCEEHARSD HHHHHHHHHHHHHCC	3.77	-
49	Phosphorylation	YCEEHARSDPLLMGI HHHHHHHCCCEECCC	44.34	21082442
59	Phosphorylation	LLMGIPTSENPFKDK EECCCCCCCCCCCCC	29.98	29899451
64	Ubiquitination	PTSENPFKDKKTCII CCCCCCCCCCCCEEE	70.65	22790023
69	Methylation	PFKDKKTCIIL---- CCCCCCCEEEC----	2.21	-
69	Geranylgeranylation	PFKDKKTCIIL---- CCCCCCCEEEC----	2.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2	S	Phosphorylation	Kinase	KPCA	P20444	PhosphoELM
2	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
2	S	Phosphorylation	Kinase	PRKCB	P68403	GPS
2	S	Phosphorylation	Kinase	PRKCD	P09215	GPS
2	S	Phosphorylation	Kinase	PRKCE	P09216	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBG12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBG12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GBG12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-26, AND MASSSPECTROMETRY.
PubMed: 19144319