STA5B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STA5B_MOUSE
• UniProt AC: P42232
• Protein Name: Signal transducer and activator of transcription 5B
• Gene Name: Stat5b
• Organism: Mus musculus (Mouse).
• Sequence Length: 786
• Subcellular Localization: Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
• Protein Description: Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation..
• Protein Sequence: MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGSGATYMDQAPSPVVCPQAHYNMYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	LKIKLGHYATQLQST EEEEHHHHHHHHHHH	15.00	-
114	Phosphorylation	RCIRHILYNEQRLVR HHHHHHHHCHHHHHH	18.95	22817900
127	Phosphorylation	VREANNGSSPAGSLA HHHHCCCCCCCCHHH	34.96	25521595
128	Phosphorylation	REANNGSSPAGSLAD HHHCCCCCCCCHHHH	21.84	25521595
132	Phosphorylation	NGSSPAGSLADAMSQ CCCCCCCHHHHHHHH	23.61	24453211
138	Phosphorylation	GSLADAMSQKHLQIN CHHHHHHHHHHHHHC	37.49	28285833
171	Phosphorylation	KLQQTQEYFIIQYQE HHHHHHHEEHEEHHH	7.11	-
232	Ubiquitination	YRVELAEKHQKTLQL HHHHHHHHHHHHHHH	45.81	27667366
279	S-palmitoylation	LDVLQSWCEKLAEII HHHHHHHHHHHHHHH	3.91	28680068
420	Phosphorylation	SAHFRNMSLKRIKRS HHHHHHCCHHHHHHH	34.00	22942356
516	Ubiquitination	EALNMKFKAEVQSNR HHHCCHHHHHHHHCC	37.81	27667366
682	Phosphorylation	KDEVYSKYYTPVPCE CCCHHHCCCCCCCCC	13.46	-
699	Phosphorylation	TAKAADGYVKPQIKQ CHHHCCCCCCHHHHH	13.07	25521595
730	Phosphorylation	TYMDQAPSPVVCPQA CCCCCCCCCEECCCC	33.08	12091337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
699	Y	Phosphorylation	Kinase	INSR	P06213	PSP
699	Y	Phosphorylation	Kinase	JAK2	O60674	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Cbl	P22682	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STA5B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STA5B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPJ_HUMAN	CENPJ	physical	12198240
STA5A_MOUSE	Stat5a	physical	12198240

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.