ST17A_HUMAN - dbPTM
ST17A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ST17A_HUMAN
UniProt AC Q9UEE5
Protein Name Serine/threonine-protein kinase 17A
Gene Name STK17A
Organism Homo sapiens (Human).
Sequence Length 414
Subcellular Localization Nucleus .
Protein Description Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species..
Protein Sequence MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MIPLEKPGSGGSS
--CCCCCCCCCCCCC		63.4624816145
9PhosphorylationIPLEKPGSGGSSPGA
CCCCCCCCCCCCCCC		48.8129255136
12PhosphorylationEKPGSGGSSPGATSG
CCCCCCCCCCCCCCC		36.5629255136
13PhosphorylationKPGSGGSSPGATSGS
CCCCCCCCCCCCCCC		30.5429255136
17PhosphorylationGGSSPGATSGSGRAG
CCCCCCCCCCCCCCC		39.2629255136
18PhosphorylationGSSPGATSGSGRAGR
CCCCCCCCCCCCCCC		30.3529255136
20PhosphorylationSPGATSGSGRAGRGL
CCCCCCCCCCCCCCC		25.5229255136
28PhosphorylationGRAGRGLSGPCRPPP
CCCCCCCCCCCCCCC		43.4429255136
71UbiquitinationGRELGRGKFAVVRKC
CCCCCCCCEEEEHHH		28.87-
83PhosphorylationRKCIKKDSGKEFAAK
HHHHHCCCCHHHHHH		61.7226074081
90UbiquitinationSGKEFAAKFMRKRRK
CCHHHHHHHHHHHHC		35.94-
97UbiquitinationKFMRKRRKGQDCRME
HHHHHHHCCCCCCHH		66.0321963094
188UbiquitinationDVVHLDLKPQNILLT
CEECCCCCCCCEEEE		44.2021963094
215UbiquitinationFGLSRILKNSEELRE
HHHHHHHCCHHHHHH		56.9329967540
226PhosphorylationELREIMGTPEYVAPE
HHHHHHCCCCHHCHH		8.7921955146
229PhosphorylationEIMGTPEYVAPEILS
HHHCCCCHHCHHHHC		11.7821955146
236PhosphorylationYVAPEILSYDPISMA
HHCHHHHCCCCCCHH		32.9021955146
237PhosphorylationVAPEILSYDPISMAT
HCHHHHCCCCCCHHH		23.4621955146
241PhosphorylationILSYDPISMATDMWS
HHCCCCCCHHHHHHH		14.0421955146
244PhosphorylationYDPISMATDMWSIGV
CCCCCHHHHHHHHHH		20.1121955146
248PhosphorylationSMATDMWSIGVLTYV
CHHHHHHHHHHHHHH		11.6521955146
253PhosphorylationMWSIGVLTYVMLTGI
HHHHHHHHHHHHHCC		16.2121955146
254PhosphorylationWSIGVLTYVMLTGIS
HHHHHHHHHHHHCCC		4.6221955146
258PhosphorylationVLTYVMLTGISPFLG
HHHHHHHHCCCCCCC		17.8621955146
261PhosphorylationYVMLTGISPFLGNDK
HHHHHCCCCCCCCCC		15.7921955146
295UbiquitinationDVLSESAVDFIRTLL
HHHCHHHHHHHHHHH		9.5724816145
304UbiquitinationFIRTLLVKKPEDRAT
HHHHHHCCCHHHCCC		63.68-
317UbiquitinationATAEECLKHPWLTQS
CCHHHHHHCCCCCHH		60.3229967540
330PhosphorylationQSSIQEPSFRMEKAL
HHCCCCCCHHHHHHH		25.4025159151
348PhosphorylationNALQEGHSVPEINSD
HHHHCCCCCCCCCCC		50.6625159151
354PhosphorylationHSVPEINSDTDKSET
CCCCCCCCCCCHHHC		47.7725159151
356PhosphorylationVPEINSDTDKSETKE
CCCCCCCCCHHHCHH		45.1820071362
386UbiquitinationGQCRQSEKEKMEQKA
HCCCHHHHHHHHHHH		68.8124816145
414PhosphorylationEIPGEFIY-------
HCCCCCCC-------		20.1627642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ST17A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ST17A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ST17A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ST17A_HUMANSTK17Aphysical
9786912
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ST17A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-28, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND MASSSPECTROMETRY.

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