SRCN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRCN1_RAT
• UniProt AC: Q9QXY2
• Protein Name: SRC kinase signaling inhibitor 1
• Gene Name: Srcin1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1197
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Localized to the perinuclear region, lamellopodia, cortical actin
• Protein Description: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance..
• Protein Sequence: MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTSQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSPQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLAQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGTPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKLRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQGPAGSPDKGKHGKQRTEYMRIQAQQQVRVGYQAPRPLEGCTPRLCYMPLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	GEPDPERSSPPMLSA CCCCCCCCCCCCCCC	45.60	30240740
47	Phosphorylation	EPDPERSSPPMLSAD CCCCCCCCCCCCCCC	38.96	30240740
52	Phosphorylation	RSSPPMLSADDAEYP CCCCCCCCCCCCCCC	24.33	-
64	Phosphorylation	EYPREYRTLGGGGSG CCCCHHCCCCCCCCC	28.93	25403869
70	Phosphorylation	RTLGGGGSGGSGGRR CCCCCCCCCCCCCCC	43.16	25403869
73	Phosphorylation	GGGGSGGSGGRRFSN CCCCCCCCCCCCCCC	41.41	25403869
79	Phosphorylation	GSGGRRFSNVGLVHT CCCCCCCCCCCEEEC	28.88	30411139
86	Phosphorylation	SNVGLVHTSERRHTV CCCCEEECCCCCCCE	25.46	25403869
87	Phosphorylation	NVGLVHTSERRHTVI CCCEEECCCCCCCEE	17.77	25403869
92	Phosphorylation	HTSERRHTVIAAQSL ECCCCCCCEEEHHHH	16.28	27097102
98	Phosphorylation	HTVIAAQSLEALSGL CCEEEHHHHHHHHCH	24.37	27097102
122	Ubiquitination	DAFMDHLKSKYPQHA HHHHHHHHHHCHHHH	41.29	-
124	Ubiquitination	FMDHLKSKYPQHALA HHHHHHHHCHHHHHH	60.40	-
125	Phosphorylation	MDHLKSKYPQHALAL HHHHHHHCHHHHHHH	18.40	-
146	Phosphorylation	MREQQPNYWSFKTRS HHHHCCCCCCCCCCC	14.76	-
172	Phosphorylation	ADQAAKLSYASAESL HHHHHHHHHHCHHHH	20.25	22673903
173	Phosphorylation	DQAAKLSYASAESLE HHHHHHHHHCHHHHH	18.27	22673903
175	Phosphorylation	AAKLSYASAESLETM HHHHHHHCHHHHHHC	25.08	22673903
178	Phosphorylation	LSYASAESLETMSEA HHHHCHHHHHHCCCC	31.08	22673903
181	Phosphorylation	ASAESLETMSEAELP HCHHHHHHCCCCCCC	31.15	22673903
183	Phosphorylation	AESLETMSEAELPLG HHHHHHCCCCCCCCC	40.86	22673903
200	Phosphorylation	RMNRFRQSLPLSRSA HHHHHHHHCCCCCCC	27.91	30411139
204	Phosphorylation	FRQSLPLSRSASQTK HHHHCCCCCCCCCCC	23.42	25403869
206	Phosphorylation	QSLPLSRSASQTKLR HHCCCCCCCCCCCCC	28.97	25403869
214	Phosphorylation	ASQTKLRSPGVLFLQ CCCCCCCCCCEEEEE	36.12	30240740
254	Phosphorylation	HMFPQKLTMGMLKSP HHCCCCCCCCCCCCC	20.79	25403869
260	Phosphorylation	LTMGMLKSPNTAILI CCCCCCCCCCEEEEE	21.30	30411139
263	Phosphorylation	GMLKSPNTAILIKDE CCCCCCCEEEEEEHH	20.61	30240740
268	Ubiquitination	PNTAILIKDEARNVF CCEEEEEEHHHHHHE	46.18	-
276	Phosphorylation	DEARNVFYELEDVRD HHHHHHEEEEHHHHC	18.47	-
291	Ubiquitination	IQDRSIIKIYRKEPL CCCCCCEEEEECCCC	31.83	-
293	Phosphorylation	DRSIIKIYRKEPLYA CCCCEEEEECCCCEE	15.61	-
299	Phosphorylation	IYRKEPLYAAFPGSH EEECCCCEEECCCCC	13.44	-
318	Phosphorylation	DLRREMVYASRESSP CHHHHHHHHCCCCCC	9.50	25403869
320	Phosphorylation	RREMVYASRESSPTR HHHHHHHCCCCCCCC	20.92	25403869
323	Phosphorylation	MVYASRESSPTRRLN HHHHCCCCCCCCCCC	40.27	28432305
324	Phosphorylation	VYASRESSPTRRLNN HHHCCCCCCCCCCCC	26.07	28432305
326	Phosphorylation	ASRESSPTRRLNNLS HCCCCCCCCCCCCCC	30.30	28432305
333	Phosphorylation	TRRLNNLSPASHLAS CCCCCCCCHHHHHHC	22.12	28432305
336	Phosphorylation	LNNLSPASHLASSSP CCCCCHHHHHHCCCC	23.55	28432305
340	Phosphorylation	SPASHLASSSPPPGL CHHHHHHCCCCCCCC	37.40	28432305
341	Phosphorylation	PASHLASSSPPPGLP HHHHHHCCCCCCCCC	41.06	28432305
342	Phosphorylation	ASHLASSSPPPGLPS HHHHHCCCCCCCCCC	38.64	27097102
349	Phosphorylation	SPPPGLPSGLPSGLP CCCCCCCCCCCCCCC	58.99	28432305
353	Phosphorylation	GLPSGLPSGLPSGSP CCCCCCCCCCCCCCC	58.99	28432305
357	Phosphorylation	GLPSGLPSGSPSRSR CCCCCCCCCCCCCCC	57.87	28432305
359	Phosphorylation	PSGLPSGSPSRSRLS CCCCCCCCCCCCCCC	24.84	27097102
361	Phosphorylation	GLPSGSPSRSRLSYA CCCCCCCCCCCCCCC	44.58	28432305
364	Methylation	SGSPSRSRLSYAGGR CCCCCCCCCCCCCCC	26.92	-
366	Phosphorylation	SPSRSRLSYAGGRPP CCCCCCCCCCCCCCC	16.30	28432305
367	Phosphorylation	PSRSRLSYAGGRPPS CCCCCCCCCCCCCCH	17.54	27097102
371	Methylation	RLSYAGGRPPSYAGS CCCCCCCCCCHHCCC	38.75	-
374	Phosphorylation	YAGGRPPSYAGSPVH CCCCCCCHHCCCHHH	30.23	27097102
375	Phosphorylation	AGGRPPSYAGSPVHH CCCCCCHHCCCHHHH	22.28	27097102
378	Phosphorylation	RPPSYAGSPVHHAAE CCCHHCCCHHHHHHH	18.64	27097102
393	Phosphorylation	RLGGAPTSQGVSPSP HHCCCCCCCCCCCCH	24.71	-
397	Phosphorylation	APTSQGVSPSPSAIL CCCCCCCCCCHHHHH	26.87	25403869
399	Phosphorylation	TSQGVSPSPSAILER CCCCCCCCHHHHHHH	24.79	25403869
401	Phosphorylation	QGVSPSPSAILERRD CCCCCCHHHHHHHCC	32.07	27115346
410	Ubiquitination	ILERRDVKPDEDLAG HHHHCCCCCCHHHCC	51.55	-
426	Ubiquitination	AGGMVLVKGEGLYAD CCCEEEEECCCCEEC	47.27	-
431	Phosphorylation	LVKGEGLYADPYGLL EEECCCCEECCCCCC	21.58	-
435	Phosphorylation	EGLYADPYGLLHEGR CCCEECCCCCCCCCC	22.43	-
462	Phosphorylation	YPGAGGLYKRGSVRS CCCCCCCCCCCCCEE	11.25	-
463	Ubiquitination	PGAGGLYKRGSVRSL CCCCCCCCCCCCEEC	56.15	-
488	Ubiquitination	DLEDSLYKAGAGGPL CHHHHHHHCCCCCCC	45.71	-
496	Phosphorylation	AGAGGPLYGDGYGFR CCCCCCCCCCCCCCC	19.12	-
507	Phosphorylation	YGFRLPPSSPQKLAD CCCCCCCCCCCHHCC	53.35	28432305
508	Phosphorylation	GFRLPPSSPQKLADV CCCCCCCCCCHHCCC	36.80	28432305
516	Phosphorylation	PQKLADVSAPSGGPP CCHHCCCCCCCCCCC	34.70	27097102
519	Phosphorylation	LADVSAPSGGPPPPH HCCCCCCCCCCCCCC	56.98	27097102
527	Phosphorylation	GGPPPPHSPYSGPPS CCCCCCCCCCCCCCC	31.16	27097102
529	Phosphorylation	PPPPHSPYSGPPSRG CCCCCCCCCCCCCCC	29.31	27097102
530	Phosphorylation	PPPHSPYSGPPSRGS CCCCCCCCCCCCCCC	48.48	27097102
534	Phosphorylation	SPYSGPPSRGSPVRQ CCCCCCCCCCCCCCH	53.02	27097102
535	Methylation	PYSGPPSRGSPVRQS CCCCCCCCCCCCCHH	56.22	-
537	Phosphorylation	SGPPSRGSPVRQSFR CCCCCCCCCCCHHHC	21.07	30322021
542	Phosphorylation	RGSPVRQSFRKDSGS CCCCCCHHHCCCCCC	19.22	25403869
547	Phosphorylation	RQSFRKDSGSSSVFA CHHHCCCCCCCCEEE	43.54	27097102
549	Phosphorylation	SFRKDSGSSSVFAES HHCCCCCCCCEEEEC	24.32	27097102
550	Phosphorylation	FRKDSGSSSVFAESP HCCCCCCCCEEEECC	33.76	27097102
551	Phosphorylation	RKDSGSSSVFAESPG CCCCCCCCEEEECCC	23.97	27097102
556	Phosphorylation	SSSVFAESPGGKARS CCCEEEECCCCCCCC	25.97	30411139
595	Ubiquitination	FGPPVPAKDTETRER CCCCCCCCCHHHHHH	60.14	-
612	Phosphorylation	AMEKQIASLTGLVQS HHHHHHHHHHHHHHH	28.26	23984901
614	Phosphorylation	EKQIASLTGLVQSAL HHHHHHHHHHHHHHH	26.44	23984901
619	Phosphorylation	SLTGLVQSALLRGSE HHHHHHHHHHHCCCC	17.26	25403869
625	Phosphorylation	QSALLRGSEPETPSE HHHHHCCCCCCCCCH	43.47	25403869
629	Phosphorylation	LRGSEPETPSEKIEG HCCCCCCCCCHHCCC	42.71	27115346
631	Phosphorylation	GSEPETPSEKIEGSN CCCCCCCCHHCCCCC	59.97	-
642	Phosphorylation	EGSNGAATPSAPVCG CCCCCCCCCCCCCCC	19.76	30411139
654	Phosphorylation	VCGSGSRSSGATPVS CCCCCCCCCCCCCCC	34.52	28551015
655	Phosphorylation	CGSGSRSSGATPVSG CCCCCCCCCCCCCCC	31.19	28551015
658	Phosphorylation	GSRSSGATPVSGPPP CCCCCCCCCCCCCCC	27.96	28551015
661	Phosphorylation	SSGATPVSGPPPPAV CCCCCCCCCCCCCCC	46.95	28551015
671	Phosphorylation	PPPAVSSTPAGQPTA CCCCCCCCCCCCCCH	15.06	-
808	Phosphorylation	KQLGETLTELKAHFP HHHHHHHHHHHHHCC	46.84	28551015
878	Phosphorylation	PNNLLNQSPKKVAAE CCCCCCCCCCCHHHC	37.30	28432305
900	Phosphorylation	DFEIPPPSPPLNLHE CCCCCCCCCCCCHHH	44.94	30240740
909	Phosphorylation	PLNLHELSGPAEGTP CCCHHHCCCCCCCCC	39.48	30240740
918	Phosphorylation	PAEGTPLTPKSGNPT CCCCCCCCCCCCCCC	29.85	-
941	Phosphorylation	RNMDKAVSVEAAERD CCHHHCCCHHHHHHC	21.06	28432305
1021	Phosphorylation	EPSGRRGSDELTVPR CCCCCCCCCCCCCCC	26.54	30411139
1031	Phosphorylation	LTVPRYRTEKPSKSP CCCCCCCCCCCCCCC	39.15	28432305
1035	Phosphorylation	RYRTEKPSKSPPPPP CCCCCCCCCCCCCCC	57.76	28432305
1037	Phosphorylation	RTEKPSKSPPPPPPR CCCCCCCCCCCCCCC	47.15	28432305
1046	Phosphorylation	PPPPPRRSFPSSHGL CCCCCCCCCCCCCCC	42.67	25403869
1050	Phosphorylation	PRRSFPSSHGLTTTR CCCCCCCCCCCCCCC	23.08	25403869
1077	Phosphorylation	VFIKKAESEELEIQK EEEECCCCCCCCCCC	41.03	30240740
1094	Phosphorylation	VKLRRAVSEVVRPAS HHHHHHHHHHHCCCC	24.56	27115346
1101	Phosphorylation	SEVVRPASTPPIMAS HHHHCCCCCCCCCHH	44.09	25403869
1102	Phosphorylation	EVVRPASTPPIMASA HHHCCCCCCCCCHHC	34.88	25403869
1108	Phosphorylation	STPPIMASAIKDEDD CCCCCCHHCCCCCCC	17.10	25403869
1125	Phosphorylation	RIIAELESGGGSVPP HHHHHHHHCCCCCCC	56.19	29779826
1152	Phosphorylation	AAQGPAGSPDKGKHG HCCCCCCCCCCCCCC	31.84	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRCN1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRCN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRCN1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYPH_RAT	Syp	physical	18662323

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.