SPT22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT22_HUMAN
• UniProt AC: Q8NHS9
• Protein Name: Spermatogenesis-associated protein 22
• Gene Name: SPATA22
• Organism: Homo sapiens (Human).
• Sequence Length: 363
• Subcellular Localization: Chromosome. Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB (By similarity)..
• Protein Description: Meiosis-specific protein required for homologous recombination in meiosis I..
• Protein Sequence: MKRSLNENSARSTAGCLPVPLFNQKKRNRQPLTSNPLKDDSGISTPSDNYDFPPLPTDWAWEAVNPELAPVMKTVDTGQIPHSVSRPLRSQDSVFNSIQSNTGRSQGGWSYRDGNKNTSLKTWNKNDFKPQCKRTNLVANDGKNSCPVSSGAQQQKQLRIPEPPNLSRNKETELLRQTHSSKISGCTMRGLDKNSALQTLKPNFQQNQYKKQMLDDIPEDNTLKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKNTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFQCVSVRPASVSEQKTFQAFVKIADVEMQYYINVMNET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Phosphorylation	IPEPPNLSRNKETEL CCCCCCCCCCHHHHH	40.21	-
195	Phosphorylation	MRGLDKNSALQTLKP ECCCCCCCHHHHHCC	35.78	29978859
199	Phosphorylation	DKNSALQTLKPNFQQ CCCCHHHHHCCCHHH	37.28	29978859
222	Phosphorylation	DDIPEDNTLKETSLY HCCCCCCCCCCCEEE	52.08	26074081
226	Phosphorylation	EDNTLKETSLYQLQF CCCCCCCCEEEEHHH	23.57	26074081
227	Phosphorylation	DNTLKETSLYQLQFK CCCCCCCEEEEHHHH	26.60	26074081
229	Phosphorylation	TLKETSLYQLQFKEK CCCCCEEEEHHHHHH	13.62	26074081
238	Phosphorylation	LQFKEKASSLRIISA HHHHHHHHHHHHHHH	40.76	-
239	Phosphorylation	QFKEKASSLRIISAV HHHHHHHHHHHHHHH	26.91	-
244	Phosphorylation	ASSLRIISAVIESMK HHHHHHHHHHHHHHH	17.70	-
249	Phosphorylation	IISAVIESMKYWREH HHHHHHHHHHHHHHH	14.95	-
252	Phosphorylation	AVIESMKYWREHAQK HHHHHHHHHHHHHHH	10.89	-
269 (in isoform 3)	Phosphorylation	-	5.51	-
279	Phosphorylation	SAVTPGPYYSKTFLM HCCCCCCCCCCEEEE	26.70	17053785
280	Phosphorylation	AVTPGPYYSKTFLMR CCCCCCCCCCEEEEE	13.56	17053785

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
DESM_HUMAN	DES	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-279 AND TYR-280, ANDMASS SPECTROMETRY.
PubMed: 17053785