| UniProt ID | SPRI_DROME | |
|---|---|---|
| UniProt AC | Q8MQW8 | |
| Protein Name | Protein sprint | |
| Gene Name | spri | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1789 | |
| Subcellular Localization | ||
| Protein Description | Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP (By similarity).. | |
| Protein Sequence | MVNAVMDAIALLSSLASDLDIMLNDLRSAPSHAATATATATTTATVATATATTTANRQQQHHNHHNQQQMQSRQLHAHHWQSINNNKNNNISNKNNNNNNNNNNNINNNNNNNNHSAHPPCLIDIKLKSSRSAATKITHTTTANQLQQQQRRRVAPKPLPRPPRRTRPTGQKEVGPSEEDGDTDASDLANMTSPLSASAAATRINGLSPEVKKVQRLPLWNARNGNGSTTTHCHPTGVSVQRRLPIQSHQQRILNQRFHHQRMHHGTSEPIPSGVATPSSLDSASVDGGKSHTGNNNNINNNHNGQQSQKSQQQAGLAAKLNVLAQSNLNNNNTTNQPGSMTPASNRTGLDSNQNQKQNLNADSRRSSSVDPDADADDVVDAAHGGAFEDDMQALLPKCSRRSRDELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTFMASEGESGSGSLDWRSSCLPACSSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEETLLTDAECPQDARLAAKGKHCMLAYKRIDAKIAWPTAQLAGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 (in isoform 9) | Phosphorylation | - | 28.11 | 23607784 | |
| 14 (in isoform 4) | Phosphorylation | - | 28.11 | 23607784 | |
| 18 (in isoform 9) | Phosphorylation | - | 42.63 | 19429919 | |
| 18 (in isoform 4) | Phosphorylation | - | 42.63 | 19429919 | |
| 21 (in isoform 9) | Phosphorylation | - | 4.38 | 19429919 | |
| 21 (in isoform 4) | Phosphorylation | - | 4.38 | 19429919 | |
| 30 (in isoform 9) | Phosphorylation | - | 28.08 | 23607784 | |
| 30 (in isoform 4) | Phosphorylation | - | 28.08 | 23607784 | |
| 59 (in isoform 2) | Phosphorylation | - | 33.32 | 19429919 | |
| 60 (in isoform 2) | Phosphorylation | - | 49.72 | 19429919 | |
| 188 (in isoform 9) | Phosphorylation | - | 52.07 | 22668510 | |
| 188 (in isoform 4) | Phosphorylation | - | 52.07 | 22668510 | |
| 190 (in isoform 9) | Phosphorylation | - | 14.56 | 22668510 | |
| 190 (in isoform 4) | Phosphorylation | - | 14.56 | 22668510 | |
| 240 (in isoform 2) | Phosphorylation | - | 17.55 | 18281928 | |
| 326 (in isoform 6) | Phosphorylation | - | 13.38 | 19429919 | |
| 327 (in isoform 6) | Phosphorylation | - | 28.79 | 19429919 | |
| 364 | Phosphorylation | KQNLNADSRRSSSVD HHCCCCCCCCHHCCC | 41.42 | 25749252 | |
| 410 | Phosphorylation | SRDELSQSRTSLVSS CHHHHHHCCHHHHHC | 49.94 | 19429919 | |
| 507 (in isoform 6) | Phosphorylation | - | 4.39 | 18281928 | |
| 849 | Phosphorylation | QTFAKRLSPEGECKD HHHHHHHCCCCCCCC | 11.18 | 19429919 | |
| 1049 | Phosphorylation | EDDGGDTTPTAEGQA ECCCCCCCCCCCCCC | 37.64 | 27794539 | |
| 1062 | Phosphorylation | QANGASRSKQGSPFY CCCCCCCCCCCCCCC | 47.54 | 25749252 | |
| 1066 | Phosphorylation | ASRSKQGSPFYAEPA CCCCCCCCCCCCCHH | 40.81 | 25749252 | |
| 1069 | Phosphorylation | SKQGSPFYAEPADAL CCCCCCCCCCHHHHH | 10.92 | 18281928 | |
| 1101 | Phosphorylation | RSQMLHASQRHSEPL HHHHHHHHHHCCCCC | 11.91 | 19429919 | |
| 1105 | Phosphorylation | LHASQRHSEPLKAGF HHHHHHCCCCCCCCC | 28.95 | 19429919 | |
| 1132 | Phosphorylation | DLEKLAGSLDELKPK HHHHHHCCHHHHCCC | 38.90 | 19429919 | |
| 1704 | Phosphorylation | IPDECNGSLQTRTLP CCCCCCCCCEECCCC | 41.20 | 29892262 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPRI_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPRI_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPRI_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| INDY1_DROME | Indy | physical | 14605208 | |
| RAC2_DROME | Rac2 | physical | 14605208 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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