SPN7_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPN7_SCHPO
• UniProt AC: O60165
• Protein Name: Septin homolog spn7
• Gene Name: spn7
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 428
• Subcellular Localization: Cytoplasm. Nucleus. Forespore membrane; Peripheral membrane protein. The sporulation-specific septin complex associates to the forespore membrane and forms partial or complete ring-like structures that curl around each haploid nucleus.
• Protein Description: Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate..
• Protein Sequence: MNKGPRHRPKFLSKKGKKLRIMVAGSSYTSYQACINSLCSKQILEAETEIDPLKAHIDRILEIREFNADILEDEFHVDLTVIEVNGFGDKIDNSASFEVVTHYLESQFDQALIEESKIKRNSKFTDTRVDALLYFIAPRGHCLSEFDLEAMKRFSKRVNVIPVIGNSNAFTEEELKNFKDVIMKDLKQCNIKVFDFPWDPEEDEDEVIEDNKRLWESVPFAVSGGVSEEDEEGYQRIVKKFQWGTFVIDDPAHSDFLNLKTVLFISHLDILKSITKQTYYENYRTEKLSNDSPSNTSLSLQKQNSIVANEDKRSVNGSERTETRSSIDQSEMRTNVSDSTKSEELKKINSIKVDNTSSLKCDSYGNTKTKTNQLNCEQIGLEVISPKEFPHRTTSSRNSLPNNTTKELEMKKMDDLSHERYENLPFYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
323	Phosphorylation	NGSERTETRSSIDQS CCCCCCCCCHHCCHH	34.93	25720772
325	Phosphorylation	SERTETRSSIDQSEM CCCCCCCHHCCHHHH	38.78	29996109
326	Phosphorylation	ERTETRSSIDQSEMR CCCCCCHHCCHHHHH	27.22	29996109
330	Phosphorylation	TRSSIDQSEMRTNVS CCHHCCHHHHHHCCC	29.61	29996109
394	Phosphorylation	KEFPHRTTSSRNSLP CCCCCCCCCCCCCCC	25.35	25720772
395	Phosphorylation	EFPHRTTSSRNSLPN CCCCCCCCCCCCCCC	27.04	25720772
399	Phosphorylation	RTTSSRNSLPNNTTK CCCCCCCCCCCCCHH	44.06	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPN7_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPN7_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPN7_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPN7_SCHPO	spn7	physical	20123972
MEU14_SCHPO	meu14	genetic	20123972

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.