SPG16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPG16_HUMAN
• UniProt AC: Q8N0X2
• Protein Name: Sperm-associated antigen 16 protein
• Gene Name: SPAG16
• Organism: Homo sapiens (Human).
• Sequence Length: 631
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity)..
• Protein Description: Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity)..
• Protein Sequence: MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYEEIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKMGMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADKAREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKEKMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AAQRGMPSSAVRVLE CCCCCCCHHHHHHHH	23.26	24043423
10	Phosphorylation	AQRGMPSSAVRVLEE CCCCCCHHHHHHHHH	25.55	24043423
24	Phosphorylation	EALGMGLTAAGDARD HHHCCCCCCCCCHHH	14.56	24043423
88	Phosphorylation	QMAQEQATDTEILER HHHHHHCCCHHHHHH	43.05	25693802
90	Phosphorylation	AQEQATDTEILERKT HHHHCCCHHHHHHHC	22.14	25693802
96	Ubiquitination	DTEILERKTVLPSKH CHHHHHHHCCCCCCC	33.34	-
101	Phosphorylation	ERKTVLPSKHAVPEV HHHCCCCCCCCCHHH	32.67	24719451
139	Ubiquitination	EWYELIQKGVTELRT HHHHHHHHCCCCEEE	48.64	-
214	Ubiquitination	NKLINDLKGLKLHYA HHHHHHHCCCCCEEC	66.13	-
226	Phosphorylation	HYASYEPTIRVLHEK EECCCCCCHHHHHHH	14.96	24719451
244	Phosphorylation	LLKEKMLTSLERDKV HHHHHHHHHHHHHHH	27.97	-
245	Phosphorylation	LKEKMLTSLERDKVV HHHHHHHHHHHHHHH	25.03	-
256	Phosphorylation	DKVVGQISGLQETLK HHHHHHHHHHHHHHH	26.09	22210691
261	Phosphorylation	QISGLQETLKKLQRG HHHHHHHHHHHHHCC	30.80	30622161
270	Phosphorylation	KKLQRGHSYHGPQIK HHHHCCCCCCCCCCC	22.96	24076635
271	Phosphorylation	KLQRGHSYHGPQIKV HHHCCCCCCCCCCCC	12.72	24076635
292	O-linked_Glycosylation	ENAPEGPTQKGLREA CCCCCCCCHHHHHHH	54.49	30379171
313	Phosphorylation	KTKMKGNTKDSEFPI CCCCCCCCCCCCCCC	44.92	-
316	Phosphorylation	MKGNTKDSEFPIDMQ CCCCCCCCCCCCCCC	42.57	-
331	Phosphorylation	PNPNLNVSKESLSPA CCCCCCCCHHHCCHH	29.63	25693802
332	Acetylation	NPNLNVSKESLSPAK CCCCCCCHHHCCHHH	47.22	2520537
334	Phosphorylation	NLNVSKESLSPAKFD CCCCCHHHCCHHHHC	37.57	25693802
336	Phosphorylation	NVSKESLSPAKFDYK CCCHHHCCHHHHCHH	31.90	24719451
436	O-linked_Glycosylation	ILTFEGHSRAVWSCT EEEECCCCCEEEEEE	32.56	30379171
501	Phosphorylation	LTSSADKTLSIWDAR ECCCCCCEECHHHCC	26.70	-
503	Phosphorylation	SSADKTLSIWDARTG CCCCCEECHHHCCCC	27.19	-
517	Phosphorylation	GICEQSLYGHMHSIN CCCCHHHHHCCCCCC	15.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPG16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPG16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPG16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SETD5_HUMAN	SETD5	physical	27173435
ADCY6_HUMAN	ADCY6	physical	27173435
TCHP_HUMAN	TCHP	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.