dbPTM

SPC25_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPC25_DROME
UniProt AC	Q9V3V7
Protein Name	Kinetochore protein Spc25 {ECO:0000303\|PubMed:17895365, ECO:0000312\|EMBL:AAF54875.1}
Gene Name	Spc25 {ECO:0000312\|FlyBase:FBgn0087021}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	222
Subcellular Localization	Nucleus . Chromosome, centromere, kinetochore . Independent of microtubules (MTs) and several other known kinetochore components. Ndc80 complex has polar orientation along the spindle axis.
Protein Description	Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. [PubMed: 17895365]
Protein Sequence	MAIIMTESSYERRVKALYEKQIHMEALEAKFIKKVFKFNSNLLDVKEAASRHQRKVGKLQKVLMERREELDKRVSFIEELDRELEATKLHNLAMKDWFKQQKMLAKQRKNEIMESIHTLSKTTRTYINQEALPARVKGVTVLRGDKRDQLIPFDLKATDVEGLDSLCQHLESLNVDVAQWQQLISLAMDMAMESRAPTTPPKEADNCKSIIEIDLTSPMSHT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of SPC25_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPC25_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPC25_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPC25_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CL190_DROME	CLIP-190	physical	17534428

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPC25_DROME

Related Literatures of Post-Translational Modification