SNL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNL1_ARATH
• UniProt AC: Q9SRH9
• Protein Name: Paired amphipathic helix protein Sin3-like 1
• Gene Name: SNL1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1372
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability..
• Protein Sequence: MKRIRDDVYASGSQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVSQKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRTDTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEEDDALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDLLEQFTRFLPASLPSHSAAQHSRSQAQQYSDRGSDPPLLHQMQVEKERRRERAVALRGDYSVERYDLNDDKTMVKIQREQRKRLDKENRARRGRDLDDREAGQDNLHHFPEKRKSSRRAEALEAYSGSASHSEKDNLKSMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESITDGFQRLAGVMSKKLFSSEEQLSRPMKVEEKESEHKPELEAVKETEQCKKEYMGKSIQELDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSGSEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIERLYGDHGLDVIDILNKNPATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEKSQNDDDVLLSISAGYRQPINPNLEYEYLNRAIHEDMFKVVQFSCEELCSTKEQLSKVLRLWENFLEAVLGVPPRAKGTDLVEDVVINPKTLDVNHSTSPNGEAAVSSGGDTARLASRKLKSAANGDENSSSGTFKHGIGLLNKDSTGKENLEDVEIANRDGVACSAVKPQKEQETGNEAEKRFGKPIPMDISERAAISSISIPSGAENNHCVVGKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANGLRSDSSKGTRNSDDPEGPSRNEKEEGELSPNGDFEDNFGVYKDHGVKSTSKPENSAEAEVEADAEVENEDDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSERVLLSVRPLSKHVAAVLCDERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRNCSGGELKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYENVRVLVHEENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQTELLSVSSGKKEEGHDIVLQRNLTGLYDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYFHRKKKKKKTEQLWQRNKVRVERFHRFLSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
768	Phosphorylation	KTLDVNHSTSPNGEA CCCCCCCCCCCCCCE	25.94	30407730
769	Phosphorylation	TLDVNHSTSPNGEAA CCCCCCCCCCCCCEE	40.42	29654922
770	Phosphorylation	LDVNHSTSPNGEAAV CCCCCCCCCCCCEEH	21.27	30407730
963	Phosphorylation	EKEEGELSPNGDFED CCCCCCCCCCCCCCC	16.41	30407730
1049	Phosphorylation	EIDGKAESEGEAEGM CCCCCCCCHHHCCCC	56.62	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNL1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALY2_ARATH	ALY2	physical	19962994
ALY3_ARATH	ALY3	physical	19962994
GAT21_ARATH	GNC	physical	19962994
TRP4_ARATH	TBP1	physical	19962994
TRP2_ARATH	TRFL1	physical	19962994
TKI1_ARATH	TKI1	physical	19962994
VAL1_ARATH	HSI2	physical	19962994

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.