SNAT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNAT_HUMAN
• UniProt AC: Q16613
• Protein Name: Serotonin N-acetyltransferase
• Gene Name: AANAT
• Organism: Homo sapiens (Human).
• Sequence Length: 207
• Subcellular Localization: Cytoplasm .
• Protein Description: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin..
• Protein Sequence: MSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREAFISVLGVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLMQESLTLHRSGGHIAHLHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRRAALMCEDALVPFYERFSFHAVGPCAITVGSLTFMELHCSLRGHPFLRRNSGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTQSTHPL ------CCCCCCCCC	34.84	24043423
3	Phosphorylation	-----MSTQSTHPLK -----CCCCCCCCCC	25.82	24043423
5	Phosphorylation	---MSTQSTHPLKPE ---CCCCCCCCCCCC	28.86	24043423
5 (in isoform 2)	Phosphorylation	-	28.86	-
6	Phosphorylation	--MSTQSTHPLKPEA --CCCCCCCCCCCCC	20.07	24043423
31	Phosphorylation	PSCQRRHTLPASEFR CCCCCCCCCCHHHEE	32.40	11336675
47 (in isoform 2)	Phosphorylation	-	29.03	28348404
48 (in isoform 2)	Phosphorylation	-	10.25	28348404
50 (in isoform 2)	Phosphorylation	-	43.59	28348404
51 (in isoform 2)	Phosphorylation	-	4.96	28348404
205	Phosphorylation	HPFLRRNSGC----- CCCHHCCCCC-----	39.46	11336675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
31	T	Phosphorylation	Kinase	PKA	-	Uniprot
31	T	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
205	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
205	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
31	T	Phosphorylation	cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.	11427721
205	S	Phosphorylation	cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNAT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	25416956
BHE40_HUMAN	BHLHE40	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614163: Delayed sleep phase syndrome (DSPS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.