SLN12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLN12_HUMAN
• UniProt AC: Q8IYM2
• Protein Name: Schlafen family member 12
• Gene Name: SLFN12
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Protein Sequence: MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGYVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKGSLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
133	Phosphorylation	LYKRDITSAKVMNAT CCCCCCCHHHCCCHH	26.82	24275569
333	Phosphorylation	DNRVMQLTRKEWIQF CCCEEEEEHHHHHHH	23.85	20058876
398	Ubiquitination	TPENLCRKLFLQHEG CHHHHHHHHHHCCHH	42.46	23000965
416	Phosphorylation	LICEEMDSVRKGSLI HHHHCHHHHCCCCEE	23.63	25850435
478	Ubiquitination	TQTALTLKQKLAKIG HHHHHHHHHHHHHCC	39.90	29967540
483	Ubiquitination	TLKQKLAKIGGYTKK HHHHHHHHCCCCCHH	52.93	-
487	Phosphorylation	KLAKIGGYTKKVCVM HHHHCCCCCHHEEEE	15.35	-
490	Acetylation	KIGGYTKKVCVMTKI HCCCCCHHEEEEEEE	32.82	7380071
499	Phosphorylation	CVMTKIFYLSPEGMT EEEEEEEEECCCCCC	15.11	-
510	Phosphorylation	EGMTSCQYDLRSQVI CCCCCCCCCCCCCCC	22.67	-
518	Phosphorylation	DLRSQVIYPESYYFT CCCCCCCCCHHHHHH	11.33	-
521	Phosphorylation	SQVIYPESYYFTRRK CCCCCCHHHHHHHHH	22.19	-
522	Phosphorylation	QVIYPESYYFTRRKY CCCCCHHHHHHHHHH	10.84	-
529	Phosphorylation	YYFTRRKYLLKALFK HHHHHHHHHHHHHHH	18.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLN12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLN12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLN12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JMJD6_HUMAN	JMJD6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.