SLIK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLIK4_HUMAN
• UniProt AC: Q8IW52
• Protein Name: SLIT and NTRK-like protein 4
• Gene Name: SLITRK4
• Organism: Homo sapiens (Human).
• Sequence Length: 837
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cell membrane .
• Protein Description: It is involved in synaptogenesis and promotes synapse differentiation. [PubMed: 27812321 Suppresses neurite outgrowth (By similarity]
• Protein Sequence: MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	N-linked_Glycosylation	LYPNTFLNFSHAVSL ECCCCCCCHHHEEEE	31.98	UniProtKB CARBOHYD
301	O-linked_Glycosylation	TSLHRLVTKPPKTTN CCEEHHCCCCCCCCC	42.28	55833113
306	O-linked_Glycosylation	LVTKPPKTTNPSKIS HCCCCCCCCCHHHCC	37.26	55833119
307	O-linked_Glycosylation	VTKPPKTTNPSKISG CCCCCCCCCHHHCCC	51.78	55833125
325	N-linked_Glycosylation	GKALSNRNLSQIVSY CCCCCCCCHHHHCEE	48.58	UniProtKB CARBOHYD
334	O-linked_Glycosylation	SQIVSYQTRVPPLTP HHHCEEECCCCCCCC	25.96	OGP
381	Acetylation	PKPLNAKKLHVNGNS CCCCCCCEEEECCCC	41.22	18528567
663	Phosphorylation	LGNPDCGSMQLQLRK CCCCCCHHHHHHHHH	15.08	20873877
718	Ubiquitination	FSDPPGQKVVMRNVA CCCCCCCEEEEEECC	42.59	23503661
736	Phosphorylation	KDLLHVDTRKRLSTI CCCCCCCHHHHCCCH	36.68	-
741	Phosphorylation	VDTRKRLSTIDELDE CCHHHHCCCHHHHHH	27.61	30266825
742	Phosphorylation	DTRKRLSTIDELDEL CHHHHCCCHHHHHHH	36.72	30266825
755	Phosphorylation	ELFPSRDSNVFIQNF HHCCCCCCCHHHHHH	33.51	22617229
765	Phosphorylation	FIQNFLESKKEYNSI HHHHHHHCCHHHCCC	51.69	29449344
766	Ubiquitination	IQNFLESKKEYNSIG HHHHHHCCHHHCCCC	40.00	23503661
767	Ubiquitination	QNFLESKKEYNSIGV HHHHHCCHHHCCCCC	74.78	23503661
769	Phosphorylation	FLESKKEYNSIGVSG HHHCCHHHCCCCCCC	24.08	25159151
792	Methylation	QPDKKSKKSLIGGNH CCCCCCCCCCCCCCC	58.55	23644510
801	Methylation	LIGGNHSKIVVEQRK CCCCCCCCEEEEECC	31.78	23644510
809	Phosphorylation	IVVEQRKSEYFELKA EEEEECCHHHHHHHH	39.45	26356563
811	Phosphorylation	VEQRKSEYFELKAKL EEECCHHHHHHHHHH	14.94	26356563
824	Phosphorylation	KLQSSPDYLQVLEEQ HHHCCHHHHHHHHHH	11.47	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLIK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLIK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLIK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNPY3_HUMAN	CNPY3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.