SIX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIX5_HUMAN
• UniProt AC: Q8N196
• Protein Name: Homeobox protein SIX5
• Gene Name: SIX5
• Organism: Homo sapiens (Human).
• Sequence Length: 739
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity)..
• Protein Sequence: MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEPLEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	AGAEGPGSPGVPGSP CCCCCCCCCCCCCCC	22.93	26029660
72	Phosphorylation	GSPGVPGSPPEAASE CCCCCCCCCCHHHCC	31.08	26029660
121	Methylation	LPPAERLRGSDPVLR CCHHHHHCCCCHHHH	49.11	115917005
123	Phosphorylation	PAERLRGSDPVLRAR HHHHHCCCCHHHHHH	32.10	24719451
140	Phosphorylation	VAFQRGEYAELYRLL HHHHHCCHHHHHHHH	14.27	-
168	Methylation	QDLYLRARYHEAERA HHHHHHHHHHHHHHH	27.23	115917009
209	Ubiquitination	EETVYCFKERSRAAL CCEEECCHHHHHHHH	48.97	29967540
268	Phosphorylation	GGGAPCKSESDGNPT CCCCCCCCCCCCCCC	49.39	23186163
270	Phosphorylation	GAPCKSESDGNPTTE CCCCCCCCCCCCCCC	58.89	23312004
275	Phosphorylation	SESDGNPTTEDESSR CCCCCCCCCCCCCCC	46.98	29255136
276	Phosphorylation	ESDGNPTTEDESSRS CCCCCCCCCCCCCCC	42.57	29255136
280	Phosphorylation	NPTTEDESSRSPEDL CCCCCCCCCCCHHHH	43.29	30576142
281	Phosphorylation	PTTEDESSRSPEDLE CCCCCCCCCCHHHHH	34.43	25849741
283	Phosphorylation	TEDESSRSPEDLERG CCCCCCCCHHHHHCC	34.29	25849741
354	Phosphorylation	GLALGEASSLGPLLL CEECCCHHHCCCEEC	23.07	-
355	Phosphorylation	LALGEASSLGPLLLT EECCCHHHCCCEECC	44.38	-
380	Phosphorylation	SPQGASETKTSLVLD CCCCCCCCCEEEEEC	36.81	-
730	Phosphorylation	KVLTQLQSVPVEEPL HHHHHHCCCCCCCCC	36.66	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIX5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIX5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EYA3_HUMAN	EYA3	physical	10490620
SNX25_HUMAN	SNX25	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.