SIM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIM1_HUMAN
• UniProt AC: P81133
• Protein Name: Single-minded homolog 1
• Gene Name: SIM1
• Organism: Homo sapiens (Human).
• Sequence Length: 766
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult..
• Protein Sequence: MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	AKLLPLPSAITSQLD HHHCCCCHHHHHCCC	39.73	-
34	Phosphorylation	LPLPSAITSQLDKAS CCCCHHHHHCCCHHH	15.33	-
35	Phosphorylation	PLPSAITSQLDKASI CCCHHHHHCCCHHHH	23.72	-
237	Phosphorylation	NMFMFRASLDMKLIF CEEEEEEECCCEEEE	22.20	24719451
335	Phosphorylation	VNYVLTDTEYKGLQL EEEEEECCCCCCEEE	35.66	30631047
343	Phosphorylation	EYKGLQLSLDQISAS CCCCEEEEHHHHHCC	19.55	-
350	Phosphorylation	SLDQISASKPAFSYT EHHHHHCCCCCCEEC	32.17	21214269
355	Phosphorylation	SASKPAFSYTSSSTP HCCCCCCEECCCCCC	29.61	-
356	Phosphorylation	ASKPAFSYTSSSTPT CCCCCCEECCCCCCC	12.27	21214269
358	Phosphorylation	KPAFSYTSSSTPTMT CCCCEECCCCCCCCC	17.66	-
382	Phosphorylation	LSSSKSKSRTSPYPQ HCCCCCCCCCCCCCC	48.13	28857561
384	Phosphorylation	SSKSKSRTSPYPQYS CCCCCCCCCCCCCCC	40.94	28857561
385	Phosphorylation	SKSKSRTSPYPQYSG CCCCCCCCCCCCCCC	22.71	28857561
477	Phosphorylation	GRCEAGRYFLGTPQA CCCCCCCEECCCCCC	11.39	24719451
481	Phosphorylation	AGRYFLGTPQAGREP CCCEECCCCCCCCCC	17.86	24719451
499	Phosphorylation	SRAALPLTKASPESR CCCCCCCCCCCHHHH	23.71	28857561
502	Phosphorylation	ALPLTKASPESREAY CCCCCCCCHHHHHHH	30.65	28857561
642	Phosphorylation	QREGKMLSPHENDYD HHCCCCCCCCCCCCC	22.25	22617229
651	Phosphorylation	HENDYDNSPTALSRI CCCCCCCCCCHHHHC	22.26	28857561
670	Phosphorylation	SDRISKSSLILAKDY CCCCCHHHHHHHHHH	24.14	-
737	Phosphorylation	YSLGCNGSHFDVTSH CCCCCCCCCCCCCCC	13.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARNT_HUMAN	ARNT	physical	9020169
HS90A_HUMAN	HSP90AA1	physical	9020169

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.