SH2D3_HUMAN - dbPTM
SH2D3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SH2D3_HUMAN
UniProt AC Q8N5H7
Protein Name SH2 domain-containing protein 3C
Gene Name SH2D3C
Organism Homo sapiens (Human).
Sequence Length 860
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein. Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity)..
Protein Description Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity)..
Protein Sequence MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Acetylation-MTEGTKKTSKKFKF
-CCCCCCCCCCCCCE		58.847365653
22PhosphorylationFKFKGFGSLSNLPRS
EEECCCCCCCCCCCC		26.7728450419
24PhosphorylationFKGFGSLSNLPRSFT
ECCCCCCCCCCCCEE		37.7130131370
24 (in isoform 2)Phosphorylation-37.7128152594
26 (in isoform 2)Phosphorylation-3.1528152594
31PhosphorylationSNLPRSFTLRRSSAS
CCCCCCEEECCCCCC		22.1724719451
36PhosphorylationSFTLRRSSASISRQS
CEEECCCCCCHHCCC		24.9928857561
49PhosphorylationQSHLEPDTFEATQDD
CCCCCCCCEECCCCC		33.8130108239
53PhosphorylationEPDTFEATQDDMVTV
CCCCEECCCCCCEEC		25.9030108239
59PhosphorylationATQDDMVTVPKSPPA
CCCCCCEECCCCCCC		25.1828450419
63PhosphorylationDMVTVPKSPPAYARS
CCEECCCCCCCCCCC		30.0028450419
67PhosphorylationVPKSPPAYARSSDMY
CCCCCCCCCCCCCCH		14.3427642862
74PhosphorylationYARSSDMYSHMGTMP
CCCCCCCHHHCCCCC		10.62-
79PhosphorylationDMYSHMGTMPRPSIK
CCHHHCCCCCCHHHH		19.2123684312
84PhosphorylationMGTMPRPSIKKAQNS
CCCCCCHHHHHHHHH		48.6019581576
113 (in isoform 4)Phosphorylation-60.6728152594
115 (in isoform 4)Phosphorylation-68.3428152594
181PhosphorylationAGEPEAGSDYVKFSK
CCCCCCCCCCEEECC		32.5829978859
183PhosphorylationEPEAGSDYVKFSKEK
CCCCCCCCEEECCCC		13.7729978859
187PhosphorylationGSDYVKFSKEKYILD
CCCCEEECCCCEECC		33.9029978859
190UbiquitinationYVKFSKEKYILDSSP
CEEECCCCEECCCCH		41.13-
191PhosphorylationVKFSKEKYILDSSPE
EEECCCCEECCCCHH		14.0623403867
195PhosphorylationKEKYILDSSPEKLHK
CCCEECCCCHHHHHH		44.3323403867
196PhosphorylationEKYILDSSPEKLHKE
CCEECCCCHHHHHHH		36.4223403867
199UbiquitinationILDSSPEKLHKELEE
ECCCCHHHHHHHHHH		60.31-
202UbiquitinationSSPEKLHKELEEELK
CCHHHHHHHHHHHHC		74.55-
211PhosphorylationLEEELKLSSTDLRSH
HHHHHCCCCHHHHHH		29.6024702127
212PhosphorylationEEELKLSSTDLRSHA
HHHHCCCCHHHHHHH		36.0618491316
213PhosphorylationEELKLSSTDLRSHAW
HHHCCCCHHHHHHHH		35.3618491316
277PhosphorylationVVVKAGESYTHIQYL
EEEECCCCCHHHHHH		34.1225884760
278PhosphorylationVVKAGESYTHIQYLF
EEECCCCCHHHHHHH		9.6825884760
283PhosphorylationESYTHIQYLFEQESF
CCCHHHHHHHCCCCC		16.86-
316PhosphorylationEQSGAIIYCPVNRTF
CCCCCEEEECCCCCC		5.6523917254
327PhosphorylationNRTFPLRYLEASYGL
CCCCCHHHHHHHHCC		19.3123403867
331PhosphorylationPLRYLEASYGLGQGS
CHHHHHHHHCCCCCC		15.4523403867
332PhosphorylationLRYLEASYGLGQGSS
HHHHHHHHCCCCCCC		24.3423403867
338PhosphorylationSYGLGQGSSKPASPV
HHCCCCCCCCCCCCC		27.5723403867
339PhosphorylationYGLGQGSSKPASPVS
HCCCCCCCCCCCCCC		49.8623403867
340UbiquitinationGLGQGSSKPASPVSP
CCCCCCCCCCCCCCC		46.42-
343PhosphorylationQGSSKPASPVSPSGP
CCCCCCCCCCCCCCC		34.0723401153
346PhosphorylationSKPASPVSPSGPKGS
CCCCCCCCCCCCCCC		19.4123401153
348PhosphorylationPASPVSPSGPKGSHM
CCCCCCCCCCCCCCC		61.2923403867
359PhosphorylationGSHMKRRSVTMTDGL
CCCCCCCEEECCCCC		26.4423403867
361PhosphorylationHMKRRSVTMTDGLTA
CCCCCEEECCCCCCC		18.6623403867
363PhosphorylationKRRSVTMTDGLTADK
CCCEEECCCCCCCCC		19.9723403867
367PhosphorylationVTMTDGLTADKVTRS
EECCCCCCCCCCCCC		38.0423403867
372PhosphorylationGLTADKVTRSDGCPT
CCCCCCCCCCCCCCC		30.1426074081
374PhosphorylationTADKVTRSDGCPTST
CCCCCCCCCCCCCCC		29.0526074081
379PhosphorylationTRSDGCPTSTSLPRP
CCCCCCCCCCCCCCC		49.0326074081
380PhosphorylationRSDGCPTSTSLPRPR
CCCCCCCCCCCCCCH		10.9226074081
381PhosphorylationSDGCPTSTSLPRPRD
CCCCCCCCCCCCCHH		36.4426074081
382PhosphorylationDGCPTSTSLPRPRDS
CCCCCCCCCCCCHHH		35.8226074081
389PhosphorylationSLPRPRDSIRSCALS
CCCCCHHHHHHHHHC		22.6026074081
392PhosphorylationRPRDSIRSCALSMDQ
CCHHHHHHHHHCHHH		11.3227732954
396PhosphorylationSIRSCALSMDQIPDL
HHHHHHHCHHHCCCC		11.2027732954
405PhosphorylationDQIPDLHSPMSPISE
HHCCCCCCCCCCCCC		29.6028450419
408PhosphorylationPDLHSPMSPISESPS
CCCCCCCCCCCCCCC		23.5928450419
411PhosphorylationHSPMSPISESPSSPA
CCCCCCCCCCCCCCC		35.0927732954
413PhosphorylationPMSPISESPSSPAYS
CCCCCCCCCCCCCCC		24.2427732954
415PhosphorylationSPISESPSSPAYSTV
CCCCCCCCCCCCCCC		59.2326434552
416PhosphorylationPISESPSSPAYSTVT
CCCCCCCCCCCCCCE		19.5525884760
419PhosphorylationESPSSPAYSTVTRVH
CCCCCCCCCCCEEEE		14.3025884760
420PhosphorylationSPSSPAYSTVTRVHA
CCCCCCCCCCEEEEC		20.6427732954
421PhosphorylationPSSPAYSTVTRVHAA
CCCCCCCCCEEEECC		17.1425884760
423PhosphorylationSPAYSTVTRVHAAPA
CCCCCCCEEEECCCC		27.3627732954
433PhosphorylationHAAPAAPSATALPAS
ECCCCCCCCCCCCCC		33.2623403867
435PhosphorylationAPAAPSATALPASPV
CCCCCCCCCCCCCCC		32.8223403867
440PhosphorylationSATALPASPVARRSS
CCCCCCCCCCCCCCC		20.2623401153
446PhosphorylationASPVARRSSEPQLCP
CCCCCCCCCCCCCCC		33.2423403867
447PhosphorylationSPVARRSSEPQLCPG
CCCCCCCCCCCCCCC		52.0324670416
455PhosphorylationEPQLCPGSAPKTHGE
CCCCCCCCCCCCCCC		26.9223403867
463PhosphorylationAPKTHGESDKGPHTS
CCCCCCCCCCCCCCC		49.5730108239
469PhosphorylationESDKGPHTSPSHTLG
CCCCCCCCCCCCCCC		45.5330108239
470PhosphorylationSDKGPHTSPSHTLGK
CCCCCCCCCCCCCCC		22.7530108239
472PhosphorylationKGPHTSPSHTLGKAS
CCCCCCCCCCCCCCC		28.9530108239
474PhosphorylationPHTSPSHTLGKASPS
CCCCCCCCCCCCCCC		41.3630108239
487PhosphorylationPSPSLSSYSDPDSGH
CCCCCCCCCCCCCCC		17.4522817900
488PhosphorylationSPSLSSYSDPDSGHY
CCCCCCCCCCCCCCC		44.61-
492PhosphorylationSSYSDPDSGHYCQLQ
CCCCCCCCCCCCCCC		32.6228796482
495PhosphorylationSDPDSGHYCQLQPPV
CCCCCCCCCCCCCCC		5.8421082442
511PhosphorylationGSREWAATETSSQQA
CCCCCCCCCCCHHHH		31.8630576142
513PhosphorylationREWAATETSSQQARS
CCCCCCCCCHHHHHH		29.3530576142
514PhosphorylationEWAATETSSQQARSY
CCCCCCCCHHHHHHH		21.6630576142
515PhosphorylationWAATETSSQQARSYG
CCCCCCCHHHHHHHH		33.4630576142
526UbiquitinationRSYGERLKELSENGA
HHHHHHHHHHHHCCC		63.93-
577UbiquitinationLEVGLLRKVKELLAE
CCHHHHHHHHHHHHH		58.59-
579UbiquitinationVGLLRKVKELLAEVD
HHHHHHHHHHHHHCC		45.76-
609UbiquitinationARILGVTKEMQTLMG
HHHHCCCHHHHHHHH		49.10-
668PhosphorylationRAALLHKTIQLAAEL
HHHHHHHHHHHHHHH		11.8328270605
698PhosphorylationALDMAQISRLEQTWV
HHHHHHHHHHHHHHC		20.8028111955
706PhosphorylationRLEQTWVTLRQRHTE
HHHHHHCHHHHHCCC		14.0524719451
718PhosphorylationHTEGAILYEKKLKPF
CCCCCEEEECCHHHH		21.4227642862
720UbiquitinationEGAILYEKKLKPFLK
CCCEEEECCHHHHHH		50.26-
721UbiquitinationGAILYEKKLKPFLKS
CCEEEECCHHHHHHH		50.21-
727UbiquitinationKKLKPFLKSLNEGKE
CCHHHHHHHHCCCCC		53.96-
793PhosphorylationVAHHGGLYHTNAEVK
HHHHCCCCCCCCEEE		15.18-
826PhosphorylationQMRLLWGSQGASSSQ
HHHHHHCCCCCCHHH		17.5426270265
830PhosphorylationLWGSQGASSSQARRY
HHCCCCCCHHHHHHH		37.0326270265
831PhosphorylationWGSQGASSSQARRYE
HCCCCCCHHHHHHHH		26.4026270265
832PhosphorylationGSQGASSSQARRYEK
CCCCCCHHHHHHHHH		25.9326270265
842UbiquitinationRRYEKFDKVLTALSH
HHHHHHHHHHHHHHH		42.13-
850UbiquitinationVLTALSHKLEPAVRS
HHHHHHHHCCHHHHC		51.69-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SH2D3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SH2D3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SH2D3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EFS_HUMANEFSphysical
16189514
BCAR1_HUMANBCAR1physical
10692442
CASL_HUMANNEDD9physical
10692442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SH2D3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-183, AND MASSSPECTROMETRY.

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