SGTA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGTA_RAT
• UniProt AC: O70593
• Protein Name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha
• Gene Name: Sgta
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 314
• Subcellular Localization: Cytoplasm . Nucleus . Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.
• Protein Description: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (By similarity). Binds directly to HSC70 and HSP70 and regulates their ATPase activity. [PubMed: 12878599]
• Protein Sequence: MDNRKRLAYAIIQFLHGQLRHGGLSSDAQESLEVAIQCLETAFGVTLEDSDLALPQTLPEIFEAATASKEMPQDPRGPDRTPPSEEDSAEAERLKTEGNEQMKLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSKAYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGSLDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQHSDLASLIQAGQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	DPRGPDRTPPSEEDS CCCCCCCCCCCHHHH	47.10	19700791
84	Phosphorylation	GPDRTPPSEEDSAEA CCCCCCCCHHHHHHH	55.62	25403869
88	Phosphorylation	TPPSEEDSAEAERLK CCCCHHHHHHHHHHH	31.15	25403869
95	Acetylation	SAEAERLKTEGNEQM HHHHHHHHCCCCHHH	51.23	22902405
137	Acetylation	NRAAAYSKLGNYVGA HHHHHHHHHHCHHHH	47.97	-
137	Ubiquitination	NRAAAYSKLGNYVGA HHHHHHHHHHCHHHH	47.97	-
160	Acetylation	GIDPGYSKAYGRMGL CCCCCCHHHHHHHHH	36.82	22902405
160	Ubiquitination	GIDPGYSKAYGRMGL CCCCCCHHHHHHHHH	36.82	-
200	Ubiquitination	DTYKSNLKIAELKLR CHHHHHHHHHEEEEC	44.09	-
211	Phosphorylation	LKLREAPSPTGGVGS EEECCCCCCCCCCCC	41.99	30240740
297	Phosphorylation	EFVEQIRSQVVRSRT HHHHHHHHHHHHHCC	29.02	25575281
302	Phosphorylation	IRSQVVRSRTPSASH HHHHHHHHCCCCCCH	28.97	29779826
304	Phosphorylation	SQVVRSRTPSASHEE HHHHHHCCCCCCHHH	23.88	21738781
306	Phosphorylation	VVRSRTPSASHEEQQ HHHHCCCCCCHHHHC	41.62	23712012
308	Phosphorylation	RSRTPSASHEEQQE- HHCCCCCCHHHHCC-	35.45	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGTA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGTA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGTA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTA_RAT	Sgta	physical	9557704

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81, AND MASSSPECTROMETRY.
PubMed: 16641100