SGT1B_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGT1B_ARATH
• UniProt AC: Q9SUT5
• Protein Name: Protein SGT1 homolog B {ECO:0000250|UniProtKB:Q08446}
• Gene Name: SGT1B
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Involved in plant innate immunity. Is essential for resistance conferred by multiple R genes recognizing different oomycete pathogen isolates like avirulent H.parasitica (downy mildew). Contributes additively with RAR1 to RPP5-dependent resistance. Not required for RPM1, RPS2, RPS4 and RPS5-mediated resistance. Functions as negative regulator of RPS5 accumulation by assisting its degradation. May be involved in heat shock response by associating with HSC70-1 chaperone. Required for the SCF(TIR1)-mediated degradation of Aux/IAA proteins, but maybe not for SCF(TIR1) assembly or binding to its Aux/IAA substrates. Probably required for SCF-mediated ubiquitination, by coupling HSP90 to SCF complex for ubiquitination of HSP90 client proteins. Required for the coronatine/jasmonic acid-mediated signal transduction pathway..
• Protein Sequence: MAKELAEKAKEAFLDDDFDVAVDLYSKAIDLDPNCAAFFADRAQANIKIDNFTEAVVDANKAIELEPTLAKAYLRKGTACMKLEEYSTAKAALEKGASVAPNEPKFKKMIDECDLRIAEEEKDLVQPMPPSLPSSSTTPLATEADAPPVPIPAAPAKPMFRHEFYQKPEEAVVTIFAKKVPKENVTVEFGEQILSVVIDVAGEEAYHLQPRLFGKIIPEKCRFEVLSTKVEIRLAKAEIITWASLEYGKGQSVLPKPNVSSALSQRPVYPSSKPAKDWDKLEAEVKKQEKDEKLDGDAAMNKFFSDIYSSADEDMRRAMNKSFAESNGTVLSTNWKEVGTKKVESTPPDGMELKKWEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
300	Sulfoxidation	KLDGDAAMNKFFSDI HCCHHHHHHHHHHHH	6.33	25693801
322	Phosphorylation	MRRAMNKSFAESNGT HHHHHHHHHHHHCCC	25.37	19880383
351	Sulfoxidation	ESTPPDGMELKKWEY CCCCCCCCCCCCCCC	7.70	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGT1B_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGT1B_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGT1B_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRFR1_ARATH	SRFR1	physical	21798944
MD37E_ARATH	HSC70-1	physical	18065690
HS901_ARATH	HSP90.1	physical	18065690
MD37D_ARATH	AT5G02490	physical	18065690
HSP7C_ARATH	AT3G09440	physical	18065690
MD37C_ARATH	HSP70	physical	18065690
HSP7J_ARATH	MTHSC70-2	physical	18065690
RAR1_ARATH	PBS2	physical	18032631
HS901_ARATH	HSP90.1	physical	18032631

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.