SFTA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFTA1_HUMAN
• UniProt AC: Q8IWL2
• Protein Name: Pulmonary surfactant-associated protein A1
• Gene Name: SFTPA1
• Organism: Homo sapiens (Human).
• Sequence Length: 248
• Subcellular Localization: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
• Protein Description: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).; (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. [PubMed: 17158455]
• Protein Sequence: MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Acetylation	AASGAVCEVKDVCVG HHCCCEEEEEEEECC	46.10	-
30	Hydroxylation	KDVCVGSPGIPGTPG EEEECCCCCCCCCCC	38.51	-
33	Hydroxylation	CVGSPGIPGTPGSHG ECCCCCCCCCCCCCC	46.66	-
36	Hydroxylation	SPGIPGTPGSHGLPG CCCCCCCCCCCCCCC	48.48	-
42	Hydroxylation	TPGSHGLPGRDGRDG CCCCCCCCCCCCCCC	40.12	-
51	Ubiquitination	RDGRDGLKGDPGPPG CCCCCCCCCCCCCCC	67.79	-
54	Hydroxylation	RDGLKGDPGPPGPMG CCCCCCCCCCCCCCC	66.90	-
57	Hydroxylation	LKGDPGPPGPMGPPG CCCCCCCCCCCCCCC	66.49	-
63	Hydroxylation	PPGPMGPPGEMPCPP CCCCCCCCCCCCCCC	45.72	-
67	Hydroxylation	MGPPGEMPCPPGNDG CCCCCCCCCCCCCCC	24.14	-
70	Hydroxylation	PGEMPCPPGNDGLPG CCCCCCCCCCCCCCC	62.02	-
121	Phosphorylation	FRHQILQTRGALSLQ HHHHHHHHCCCHHCC	27.85	29888752
126	Phosphorylation	LQTRGALSLQGSIMT HHHCCCHHCCCCEEE	20.36	29888752
130	Phosphorylation	GALSLQGSIMTVGEK CCHHCCCCEEEECCE	9.02	29396449
181	Nitration	IASFVKKYNTYAYVG HHHHHHHHCCEEEEE	13.66	-
184	Nitration	FVKKYNTYAYVGLTE HHHHHCCEEEEECCC	7.72	-
184	Phosphorylation	FVKKYNTYAYVGLTE HHHHHCCEEEEECCC	7.72	-
186	Nitration	KKYNTYAYVGLTEGP HHHCCEEEEECCCCC	5.66	-
207	N-linked_Glycosylation	YSDGTPVNYTNWYRG CCCCCCCCCCCCCCC	38.83	UniProtKB CARBOHYD
240	Nitration	WNDRNCLYSRLTICE CCCCCCHHCCEEEEE	8.24	-
241	Phosphorylation	NDRNCLYSRLTICEF CCCCCHHCCEEEEEC	14.09	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFTA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFTA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFTA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFTPD_HUMAN	SFTPD	physical	10101009
DMBT1_HUMAN	DMBT1	physical	10101009
SFTA1_HUMAN	SFTPA1	physical	16330552
PRDX6_HUMAN	PRDX6	physical	16330552

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 178500: Pulmonary fibrosis, idiopathic (IPF)
• 267450: Respiratory distress syndrome in premature infants (RDS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Isolation and characterization of cDNA clones for the 35-kDapulmonary surfactant-associated protein.";
Floros J., Steinbrink R., Jacobs K., Phelps D., Kriz R., Recny M.,Sultzman L., Jones S., Taeusch H.W., Frank H.A., Fritsch E.F.;
J. Biol. Chem. 261:9029-9033(1986).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-19, AND ACETYLATION AT GLU-21.
PubMed: 3755136