SETD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SETD6_HUMAN
• UniProt AC: Q8TBK2
• Protein Name: N-lysine methyltransferase SETD6
• Gene Name: SETD6
• Organism: Homo sapiens (Human).
• Sequence Length: 473
• Subcellular Localization: Nucleus .
• Protein Description: Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. [PubMed: 21131967 Monomethylates 'Lys-8' of H2AZ (H2AZK8me1)]
• Protein Sequence: MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSPPAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	RRVGLELSPKVSERA HHHCCCCCCCHHHHH	17.19	24732914
39	Ubiquitination	VGLELSPKVSERAGG HCCCCCCCHHHHHCC	55.83	21906983
39 (in isoform 1)	Ubiquitination	-	55.83	21906983
41	Phosphorylation	LELSPKVSERAGGRR CCCCCCHHHHHCCCC	27.73	24732914
118	Phosphorylation	RERVALQSQSGWVPL HHHHHHHCCCCHHHH	27.45	-
120	Phosphorylation	RVALQSQSGWVPLLL HHHHHCCCCHHHHHH	39.61	-
138	Phosphorylation	HELQAPASRWRPYFA HHHHCCHHHCCHHHH	31.17	-
155	Ubiquitination	PELGRLEHPMFWPEE CCCCCCCCCCCCCHH	24.58	21963094
179	Ubiquitination	GVPEAVEKDLANIRS CCCHHHHHHHHHHHH	51.98	21963094
272	Phosphorylation	NCLRMVATQPIPKGH HHHHHHHCCCCCCCC	24.38	22210691
303 (in isoform 2)	Ubiquitination	-	15.09	21906983
303	Ubiquitination	MYGFVEPYPDNTDDT EEEECCCCCCCCCCC	15.09	21963094
327 (in isoform 1)	Ubiquitination	-	51.71	21906983
327	Ubiquitination	EAALQGTKTEAERHL HHHHCCCCCHHHHHH	51.71	21906983
361	Ubiquitination	FVIGREEVLTEEELT EEECCCCCCCHHHHH	7.40	21963094
370	Ubiquitination	TEEELTTTLKVLCMP CHHHHHHHHHHHHCC	21.24	29967540
385	Ubiquitination	AEEFRELKDQDGGGD HHHHHHHHCCCCCCC	48.90	21963094
394	Ubiquitination	QDGGGDDKREEGSLT CCCCCCCCCCCCCEE	67.46	29967540
399	Phosphorylation	DDKREEGSLTITNIP CCCCCCCCEEEECHH	26.14	29083192
401	Phosphorylation	KREEGSLTITNIPKL CCCCCCEEEECHHHH	27.70	29083192
403	Phosphorylation	EEGSLTITNIPKLKA CCCCEEEECHHHHHH	23.12	29083192
411	Phosphorylation	NIPKLKASWRQLLQN CHHHHHHHHHHHHHH	22.62	29083192
417 (in isoform 2)	Ubiquitination	-	49.06	21906983
417	Ubiquitination	ASWRQLLQNSVLLTL HHHHHHHHHHHHHHH	49.06	22817900
422	Ubiquitination	LLQNSVLLTLQTYAT HHHHHHHHHHHHHHH	4.15	22817900
441 (in isoform 1)	Ubiquitination	-	45.22	21906983
441	Ubiquitination	DQGLLSNKEVYAKLS CCCCCCCHHHHHHCC	45.22	22817900
446	Ubiquitination	SNKEVYAKLSWREQQ CCHHHHHHCCHHHHH	25.93	22817900
448	Phosphorylation	KEVYAKLSWREQQAL HHHHHHCCHHHHHHH	24.31	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SETD6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SETD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SETD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF65_HUMAN	RELA	physical	21515635
TF65_HUMAN	RELA	physical	21131967

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.