dbPTM

SERF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SERF1_HUMAN
UniProt AC	O75920
Protein Name	Small EDRK-rich factor 1
Gene Name	SERF1A
Organism	Homo sapiens (Human).
Sequence Length	110
Subcellular Localization
Protein Description
Protein Sequence	MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	O-linked_Glycosylation	RQKNMKKTQEISKGK HHHHHHHHHHHHHCC	26.39	30379171
22	Phosphorylation	MKKTQEISKGKRKED HHHHHHHHHCCCHHH	34.30	26657352
27	Ubiquitination	EISKGKRKEDSLTAS HHHHCCCHHHHCCHH	70.16	29967540
30	Phosphorylation	KGKRKEDSLTASQRK HCCCHHHHCCHHHHH	28.81	24719451
32	Phosphorylation	KRKEDSLTASQRKQS CCHHHHCCHHHHHHC	28.37	25159151
32 (in isoform 2)	Phosphorylation	-	28.37	25627689
34	Phosphorylation	KEDSLTASQRKQSSG HHHHCCHHHHHHCCC	25.86	21815630
34 (in isoform 2)	Phosphorylation	-	25.86	25159151
36	Methylation	DSLTASQRKQSSGGQ HHCCHHHHHHCCCCC	36.16	24395477
41	Phosphorylation	SQRKQSSGGQKSESK HHHHHCCCCCCCCCC	48.04	24719451
41 (in isoform 2)	Phosphorylation	-	48.04	24719451
45	Phosphorylation	QSSGGQKSESKMSAG HCCCCCCCCCCCCCC	38.93	-
47	Phosphorylation	SGGQKSESKMSAGPH CCCCCCCCCCCCCCC	40.52	-
47	O-linked_Glycosylation	SGGQKSESKMSAGPH CCCCCCCCCCCCCCC	40.52	30379171
47	Ubiquitination	SGGQKSESKMSAGPH CCCCCCCCCCCCCCC	40.52	33845483
58	Ubiquitination	AGPHLPLKAPRENPC CCCCCCCCCCCCCCC	55.17	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SERF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SERF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SERF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SERF1_HUMAN

Related Literatures of Post-Translational Modification