dbPTM

SEPT4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEPT4_MOUSE
UniProt AC	P28661
Protein Name	Septin-4
Gene Name	4-Sep
Organism	Mus musculus (Mouse).
Sequence Length	478
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum . Found in the sperm annulus. Isoform 4: Mitochondrion. In retinoic acid-treated P19 cells, isoform 4 is found first in the mitochondria and at later times, as neuronal dif
Protein Description	Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)..
Protein Sequence	MDHSLGWQGNSVPEDGTEAGIKHFLEDSSDDAELSKFVKDFPGSEPYHSAESKTRVARPQILEPRPQSPDLCDDDVEFRGSLWPQPSDSQQYFSAPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	IKHFLEDSSDDAELS HHHHHHCCCCHHHHH	26.71	25521595
29	Phosphorylation	KHFLEDSSDDAELSK HHHHHCCCCHHHHHH	52.40	25521595
35	Phosphorylation	SSDDAELSKFVKDFP CCCHHHHHHHHHHCC	18.62	24925903
36	Ubiquitination	SDDAELSKFVKDFPG CCHHHHHHHHHHCCC	67.79	22790023
49	Phosphorylation	PGSEPYHSAESKTRV CCCCCCCCCCCCCCC	28.08	16452087
52	Phosphorylation	EPYHSAESKTRVARP CCCCCCCCCCCCCCC	38.76	29899451
68	Phosphorylation	ILEPRPQSPDLCDDD CCCCCCCCCCCCCCC	24.06	25521595
81	Phosphorylation	DDVEFRGSLWPQPSD CCCCCCCCCCCCCCC	24.01	25293948
87	Phosphorylation	GSLWPQPSDSQQYFS CCCCCCCCCCCCEEC	44.65	25293948
89	Phosphorylation	LWPQPSDSQQYFSAP CCCCCCCCCCEECCC	24.42	25293948
92	Phosphorylation	QPSDSQQYFSAPAPL CCCCCCCEECCCCCC	7.58	25293948
94	Phosphorylation	SDSQQYFSAPAPLSP CCCCCEECCCCCCCC	28.54	25293948
100	Phosphorylation	FSAPAPLSPSSRPRS ECCCCCCCCCCCCCC	22.98	27180971
102	Phosphorylation	APAPLSPSSRPRSPW CCCCCCCCCCCCCCC	35.29	25521595
103	Phosphorylation	PAPLSPSSRPRSPWG CCCCCCCCCCCCCCC	50.08	24925903
107	Phosphorylation	SPSSRPRSPWGKLDP CCCCCCCCCCCCCCC	27.90	24925903
115	Phosphorylation	PWGKLDPYDSSEDDK CCCCCCCCCCCCCCC	28.29	24925903
117	Phosphorylation	GKLDPYDSSEDDKEY CCCCCCCCCCCCCHH	29.77	25521595
118	Phosphorylation	KLDPYDSSEDDKEYV CCCCCCCCCCCCHHE	41.99	25521595
124	Phosphorylation	SSEDDKEYVGFATLP CCCCCCHHEEEEECC	16.18	25521595
129	Phosphorylation	KEYVGFATLPNQVHR CHHEEEEECCCHHHH	40.25	23335269
174	Ubiquitination	TDLYRDRKLLGAEER HHHHHCHHHHCCHHH	52.96	22790023
258	Phosphorylation	NRVHCCLYFISPFGH CCEEEEEEEECCCCC	5.74	21454597
261	Phosphorylation	HCCLYFISPFGHGLR EEEEEEECCCCCCCC	12.32	21454597
295	Phosphorylation	LAKADTLTPPEVDRK CCCCCCCCCHHHCHH	38.60	28059163
318	Phosphorylation	EHFGIKIYQFPDCDS HHHCEEEEECCCCCC	10.09	22324799
325	Phosphorylation	YQFPDCDSDEDEDFK EECCCCCCCCCCCCH	49.59	25521595
341	Phosphorylation	QDQALKESIPFAVIG HHHHHHHCCCEEEEC	33.69	21183079
414	Phosphorylation	YRAQCIQSMTRLVVK HHHHHHHHHHHHHHH	11.38	22324799
416	Phosphorylation	AQCIQSMTRLVVKER HHHHHHHHHHHHHHH	26.54	22324799
429	Phosphorylation	ERNRNKLTRESGTDF HHHHCCCCCCCCCCC	33.72	25521595
432	Phosphorylation	RNKLTRESGTDFPIP HCCCCCCCCCCCCCC	43.64	25521595
434	Phosphorylation	KLTRESGTDFPIPAV CCCCCCCCCCCCCCC	43.69	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
100	S	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEPT4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEPT4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
XIAP_MOUSE	Xiap	physical	21695558
BIRC3_MOUSE	Birc3	physical	21695558

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEPT4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, AND MASSSPECTROMETRY.	16452087 [Abstract]