SEM6D_HUMAN - dbPTM
SEM6D_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEM6D_HUMAN
UniProt AC Q8NFY4
Protein Name Semaphorin-6D
Gene Name SEMA6D
Organism Homo sapiens (Human).
Sequence Length 1073
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Cell membrane
Single-pass type I membrane protein.
Isoform 3: Cell membrane
Single-pass type I membrane protein.
Isoform 4: Cell membrane
Single-pass type I membrane protein.
Protein Description Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections..
Protein Sequence MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationRVFLLCAYILLLMVS
HHHHHHHHHHHHHHH		7.3624043423
16PhosphorylationYILLLMVSQLRAVSF
HHHHHHHHHHHHCCC		14.9924043423
22PhosphorylationVSQLRAVSFPEDDEP
HHHHHHCCCCCCCCC		33.8124043423
32PhosphorylationEDDEPLNTVDYHYSR
CCCCCCCCCCHHHCC		23.5724043423
35PhosphorylationEPLNTVDYHYSRQYP
CCCCCCCHHHCCCCC		9.7924043423
37PhosphorylationLNTVDYHYSRQYPVF
CCCCCHHHCCCCCCC		10.1824043423
38PhosphorylationNTVDYHYSRQYPVFR
CCCCHHHCCCCCCCC		10.2924043423
49PhosphorylationPVFRGRPSGNESQHR
CCCCCCCCCCCCCCC		53.5425262027
51N-linked_GlycosylationFRGRPSGNESQHRLD
CCCCCCCCCCCCCEE		50.51UniProtKB CARBOHYD
53PhosphorylationGRPSGNESQHRLDFQ
CCCCCCCCCCCEEHH		34.9725262027
201PhosphorylationSDAVIYRSMGDGSAL
CCCEEEEECCCCCCE		15.3321712546
206PhosphorylationYRSMGDGSALRTIKY
EEECCCCCCEEEEEE		28.9523532336
260AcetylationSRVARICKNDMGGSQ
HHHHHHHHCCCCCCH		54.327680153
272AcetylationGSQRVLEKHWTSFLK
CCHHHHHHHHHHHHH		40.047680163
276PhosphorylationVLEKHWTSFLKARLN
HHHHHHHHHHHHHHC		24.3224719451
283N-linked_GlycosylationSFLKARLNCSVPGDS
HHHHHHHCCCCCCCC		15.51UniProtKB CARBOHYD
391PhosphorylationDFPDETLSFIKSHPL
CCCHHHHHHHHHCCC		32.1424719451
435N-linked_GlycosylationHSAGPYQNYTVIFVG
CCCCCCCCEEEEEEC		28.71UniProtKB CARBOHYD
461N-linked_GlycosylationKTSPFSLNDSVLLEE
CCCCCCCCCCHHHHH		38.01UniProtKB CARBOHYD
472PhosphorylationLLEEIEAYNHAKCSA
HHHHHHHHCCCCCCC		8.4922817900
613O-linked_GlycosylationITPKVIDTWRPKLTS
CCHHHHHCCCCCCCC		16.5555825449
621PhosphorylationWRPKLTSSRKFVVQD
CCCCCCCCCCEEECC		33.9624275569
631N-linked_GlycosylationFVVQDDPNTSDFTDP
EEECCCCCCCCCCCC		60.24UniProtKB CARBOHYD
699UbiquitinationRKNRKIHKDAESAQS
HHCCCCCCCHHHHHH		63.21-
703PhosphorylationKIHKDAESAQSCTDS
CCCCCHHHHHHCCCC		33.0722617229
706PhosphorylationKDAESAQSCTDSSGS
CCHHHHHHCCCCCCC		20.7822617229
708PhosphorylationAESAQSCTDSSGSFA
HHHHHHCCCCCCCHH		44.1329759185
710PhosphorylationSAQSCTDSSGSFAKL
HHHHCCCCCCCHHHH		20.6025159151
711PhosphorylationAQSCTDSSGSFAKLN
HHHCCCCCCCHHHHC		41.0728348404
713PhosphorylationSCTDSSGSFAKLNGL
HCCCCCCCHHHHCCC		24.7925159151
723PhosphorylationKLNGLFDSPVKEYQQ
HHCCCCCCHHHHHHH		25.0221815630
728PhosphorylationFDSPVKEYQQNIDSP
CCCHHHHHHHCCCCH		15.0725884760
734PhosphorylationEYQQNIDSPKLYSNL
HHHHCCCCHHHHHHH		21.8221815630
738PhosphorylationNIDSPKLYSNLLTSR
CCCCHHHHHHHHHCC		11.1425884760
739PhosphorylationIDSPKLYSNLLTSRK
CCCHHHHHHHHHCCC		31.2923186163
743PhosphorylationKLYSNLLTSRKELPP
HHHHHHHHCCCCCCC		29.6524719451
744PhosphorylationLYSNLLTSRKELPPN
HHHHHHHCCCCCCCC		41.1323186163
754PhosphorylationELPPNGDTKSMVMDH
CCCCCCCCCCCHHCC		26.81-
756PhosphorylationPPNGDTKSMVMDHRG
CCCCCCCCCHHCCCC		20.78-
773PhosphorylationPELAALPTPESTPVL
CHHHCCCCCCCCCCC		40.3025159151
776PhosphorylationAALPTPESTPVLHQK
HCCCCCCCCCCCCHH		38.9325850435
777PhosphorylationALPTPESTPVLHQKT
CCCCCCCCCCCCHHH		18.7625850435
792PhosphorylationLQAMKSHSEKAHGHG
HHHHHHHHHHHCCCC		48.13-
837PhosphorylationLPNATHDYNTSFSNS
CCCCCCCCCCCCCCC		16.8525884760
863PhosphorylationIDHPLTKSSSKRDHR
CCCCCCCCCCCHHHH		34.31-
865PhosphorylationHPLTKSSSKRDHRRS
CCCCCCCCCHHHHHC		38.51-
878PhosphorylationRSVDSRNTLNDLLKH
HCCHHHHHHHHHHHH		26.3129978859
891PhosphorylationKHLNDPNSNPKAIMG
HHHCCCCCCHHHHHH		60.9529978859
928PhosphorylationKVPNREASLYSPPST
CCCCCCCCCCCCCCC		24.0821945579
930PhosphorylationPNREASLYSPPSTLP
CCCCCCCCCCCCCCC		19.3521945579
931PhosphorylationNREASLYSPPSTLPR
CCCCCCCCCCCCCCC		35.3121945579
934PhosphorylationASLYSPPSTLPRNSP
CCCCCCCCCCCCCCC		46.0621945579
935PhosphorylationSLYSPPSTLPRNSPT
CCCCCCCCCCCCCCC		46.7021945579
949PhosphorylationTKRVDVPTTPGVPMT
CCCCCCCCCCCCCCC		45.5322210691
950PhosphorylationKRVDVPTTPGVPMTS
CCCCCCCCCCCCCCH		16.3925159151
956PhosphorylationTTPGVPMTSLERQRG
CCCCCCCCHHHHHCC		24.8825850435
957PhosphorylationTPGVPMTSLERQRGY
CCCCCCCHHHHHCCC		23.2125159151
964PhosphorylationSLERQRGYHKNSSQR
HHHHHCCCCCCHHHC		16.2922210691
968PhosphorylationQRGYHKNSSQRHSIS
HCCCCCCHHHCCCCC		32.4322210691
969PhosphorylationRGYHKNSSQRHSISA
CCCCCCHHHCCCCCC		40.4022210691
973PhosphorylationKNSSQRHSISAMPKN
CCHHHCCCCCCCCCC		22.0425159151
975PhosphorylationSSQRHSISAMPKNLN
HHHCCCCCCCCCCCC		22.8725159151
983PhosphorylationAMPKNLNSPNGVLLS
CCCCCCCCCCCEEEE		23.9412110693
1000PhosphorylationPSMNRGGYMPTPTGA
CCCCCCCCCCCCCCC		11.6225884760
1003PhosphorylationNRGGYMPTPTGAKVD
CCCCCCCCCCCCEEE		19.5621722762
1005PhosphorylationGGYMPTPTGAKVDYI
CCCCCCCCCCEEEEE		52.8521722762
1011PhosphorylationPTGAKVDYIQGTPVS
CCCCEEEEECCCEEE		9.7225159151
1015PhosphorylationKVDYIQGTPVSVHLQ
EEEEECCCEEEEEEC		12.2525159151
1018PhosphorylationYIQGTPVSVHLQPSL
EECCCEEEEEECCCC		12.6723186163
1024PhosphorylationVSVHLQPSLSRQSSY
EEEEECCCCCCCCCC		26.4725159151
1026PhosphorylationVHLQPSLSRQSSYTS
EEECCCCCCCCCCCC		32.3925159151
1029PhosphorylationQPSLSRQSSYTSNGT
CCCCCCCCCCCCCCC		24.9723186163
1030PhosphorylationPSLSRQSSYTSNGTL
CCCCCCCCCCCCCCC		24.8825884760
1031PhosphorylationSLSRQSSYTSNGTLP
CCCCCCCCCCCCCCC		21.3125884760
1045PhosphorylationPRTGLKRTPSLKPDV
CCCCCCCCCCCCCCC		18.6823186163
1047PhosphorylationTGLKRTPSLKPDVPP
CCCCCCCCCCCCCCC		48.7023186163
1057PhosphorylationPDVPPKPSFVPQTPS
CCCCCCCCCCCCCCC		45.0329083192
1062PhosphorylationKPSFVPQTPSVRPLN
CCCCCCCCCCCCCCC		16.0925159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEM6D_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEM6D_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEM6D_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPM2_HUMANTPM2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEM6D_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1026, AND MASSSPECTROMETRY.

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