SEC8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC8_ARATH
• UniProt AC: Q93YU5
• Protein Name: Exocyst complex component SEC8
• Gene Name: SEC8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1053
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm, cytoskeleton, phragmoplast . Secreted, cell wall . Secreted, exosome . During cytokinesis, localizes to the nascent cell plate and later to the cell plate insertion site and along the post-cytokinetic wall (PubMed:2087
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in secretory processes during cell plate initiation, cell plate maturation and formation of new primary cell wall.; Participates in polarized pectin delivery required for the polarized development of the mucilage-producing volcano cells of the seed coat..
• Protein Sequence: MGIFNGLPVPSDKTYLREELARIDESWAAARFDSLPHVVHILTSKDREADIHILKEQSDVVEEVVDEVVHAYHGGFNKAIQNYSQILRLFSESTEKIGDLKHDLAEAKQSLGARNKQLHQLWYRSVTLRHIISLLDQIEGIAKVPSRIEKLIADKQFYAAIQVYLQSSLMLEREGLQTVGALQDVRSELTKLRGALFFKILDDLHAHLYNRGEYSSVASSIYERDDEVPTTTAVAASRMSSQPLSRRTRTLKGDSQFGVRGLTNGSYRTASNDESSSFDGHDEEDSVEHDESTADTARNGTDSKLLSHQLPPWLSDSTPDEFIEAVRKSDDPLHVKYLQTLVQCLCMLGKVAAAGAIICQKLRPTIHEIIISKIKAHLETTNLSKSACSQGDRSVAAGLHLIKGQSEAYRLSKEKPQNGISNSGTHLAVSPVSPLMAPGGKAQAAAKELLDSILDTIVKIFENHVVIGELLEMKASQHDINTPRSLPTDVNWNTESEASQATGGYTISFPLTVLQSECQQLICEILRATPEAASADAAAQTAKLAKKAPKKDKRDAPEDGLTFTFRFTDATVSISNQGADLIRQGWGKRAPNASLEGYGSAAVLPEQGIYLAASIYRPVLQFTDKITSMLPKKHSQLVNDGLLTFTENFVKDHLLPTMFVDYRKGVQQAISSAAAFRPRAHTTTYTATVEKGRPILQGLLAIDLLAKEVLGWAQAMPKFATDLVKYVQTFLERTFERCRTSYMEAVLEKLSYMLIGRHDIEKLMRLDAASACLPSTLGHAVSHSEAVGTEVELSDLFLSLRPIKQDNLIRDDNKLILLASLSDSLEYVADSIERLGQAVPRVASQAEGNSRNQAASPRNLASFADEYRKLATDCLKVLRVEMQLETVFHLQEMTNREYLEDEDAEEPDDFVISLTSQITRREEGMAPFISGEKRNYVFGGISGIAANASIKALADMRSINLFGVQQICRNTIAVEQAMAAIPYIDGETVQQNLDRVRTYFELLNMPFEALLAFIAEHDQMFTPTEYSNLLKVNVPGRDTPSDAQSRLLEILSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
248	Phosphorylation	SQPLSRRTRTLKGDS CCCCCCCCCCCCCCC		19376835
250	Phosphorylation	PLSRRTRTLKGDSQF CCCCCCCCCCCCCCC		30291188
255	Phosphorylation	TRTLKGDSQFGVRGL CCCCCCCCCCCCCCC		19376835
266	Phosphorylation	VRGLTNGSYRTASND CCCCCCCCEEECCCC		29654922
267	Phosphorylation	RGLTNGSYRTASNDE CCCCCCCEEECCCCC		25561503
269	Phosphorylation	LTNGSYRTASNDESS CCCCCEEECCCCCCC		23776212
271	Phosphorylation	NGSYRTASNDESSSF CCCEEECCCCCCCCC		23776212
275	Phosphorylation	RTASNDESSSFDGHD EECCCCCCCCCCCCC		23776212
276	Phosphorylation	TASNDESSSFDGHDE ECCCCCCCCCCCCCC		23776212
277	Phosphorylation	ASNDESSSFDGHDEE CCCCCCCCCCCCCCC		23776212
286	Phosphorylation	DGHDEEDSVEHDEST CCCCCCCCCCCCHHH		23776212
292	Phosphorylation	DSVEHDESTADTARN CCCCCCHHHHHHHHH		23776212
293	Phosphorylation	SVEHDESTADTARNG CCCCCHHHHHHHHHC		23776212
296	Phosphorylation	HDESTADTARNGTDS CCHHHHHHHHHCCCC		23776212
482	Phosphorylation	ASQHDINTPRSLPTD HHHCCCCCCCCCCCC		30589143
729	Phosphorylation	DLVKYVQTFLERTFE HHHHHHHHHHHHHHH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEC6_ARATH	SEC6	physical	18492870

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.